Kucharzewski M, Braziewicz J, Majewska U, Gózdz S
Department of General Surgery, Silesian Medical Academy, Batorego 15, 41-902 Bytom, Poland.
Biol Trace Elem Res. 2003 Summer;93(1-3):9-18. doi: 10.1385/BTER:93:1-3:9.
We investigated the possible differences among the concentrations of copper, zinc, and selenium, and their mutual relations in the whole blood and thyroid tissue of patients with various thyroid disorders. Trace elements were determined by total-reflection X-ray fluorescence. The mean levels of these metals in blood as well as the mean Cu/Zn, Cu/Se, and Zn/Se ratios in the patients with thyroid cancer were significantly higher that in other patients and the control groups. However, the mean Zn and Se concentrations in the thyroid cancer tissue were significantly lower than in the thyroid tissue of other patients. In addition, the mean Cu/Zn and Cu/Se ratios in the thyroid cancer tissue were significantly higher than in the patients with other thyroid diseases. We confirm that the highest levels of copper and zinc as well as the Cu/Zn, Cu/Se, and Zn/Se ratios in the whole blood of the patients with thyroid cancer may suggest the progression of the proliferation process in the thyroid gland. We suggest that the low concentrations of zinc and selenium in the thyroid tissue confirm their participation in the carcinogenic process.
我们研究了各种甲状腺疾病患者全血和甲状腺组织中铜、锌、硒浓度的可能差异及其相互关系。采用全反射X射线荧光法测定微量元素。甲状腺癌患者血液中这些金属的平均水平以及平均铜/锌、铜/硒和锌/硒比值显著高于其他患者和对照组。然而，甲状腺癌组织中锌和硒的平均浓度显著低于其他患者的甲状腺组织。此外，甲状腺癌组织中的平均铜/锌和铜/硒比值显著高于其他甲状腺疾病患者。我们证实，甲状腺癌患者全血中铜和锌的最高水平以及铜/锌、铜/硒和锌/硒比值可能提示甲状腺腺体内增殖过程的进展。我们认为，甲状腺组织中锌和硒的低浓度证实了它们参与致癌过程。
