Faculty of Health Sciences, School of Socio-Economics in Sroda Wielkopolska, 63-000 Sroda Wielkopolska, Poland.
Department of Physiology and Biochemistry, Poznan University of Physical Education, 61-871 Poznan, Poland.
Int J Environ Res Public Health. 2021 Jul 23;18(15):7805. doi: 10.3390/ijerph18157805.
The aim of this study was to analyze selected indicators of oxidative stress. The study subjects consisted of 42 women with Hashimoto's disease and a control group of 30 healthy women. The concentration of zinc (Zn) and copper (Cu) in the serum was determined by Atomic Absorption Spectrometry (AAS) and the total antioxidative potential by the Ferric Reducing Ability of Plasma (FRAP) method. In addition, an assessment of concentrations of thiobarbituric acid reactive substances (TBARS) and total phenolics was carried out. Our research showed a significant difference in TBARS concentration ( < 0.0001 (ES: 0.92)) without significant differences in Zn, Cu, FRAP and total phenolics concentrations. Analysis of the correlation of the obtained results of biochemical tests for both groups showed a highly significant dependence of FRAP and total phenolics concentration in the blood of the examined women ( = 0.5283, = 0.0003). The obtained results indicate no differences in Cu, Zn, and FRAP concentrations in the blood between two analyzed groups and a significantly higher concentration of TBARS in Hashimoto's thyroiditis women. The concentration of total phenolics significantly influences the value of the FRAP.
本研究旨在分析氧化应激的某些指标。研究对象为 42 名桥本氏病女性和 30 名健康女性。采用原子吸收光谱法（AAS）测定血清中锌（Zn）和铜（Cu）的浓度，采用血浆铁还原能力（FRAP）法测定总抗氧化能力。此外，还评估了丙二醛（TBARS）和总酚的浓度。我们的研究表明，TBARS 浓度存在显著差异（<0.0001（ES：0.92）），而 Zn、Cu、FRAP 和总酚浓度无显著差异。对两组生化测试结果的相关性分析表明，检查女性血液中的 FRAP 和总酚浓度存在高度显著的依赖性（=0.5283，=0.0003）。研究结果表明，两组之间血液中 Cu、Zn 和 FRAP 浓度无差异，桥本氏甲状腺炎女性的 TBARS 浓度显著升高。总酚的浓度显著影响 FRAP 的值。
