Louis S M, Pearson R M
Contraception. 1985 Aug;32(2):199-205. doi: 10.1016/0010-7824(85)90108-8.
The effects of Nonoxynol-9 and chlorhexidine on sperm motility were compared using the objective Transmembrane Migration Ratio method. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50% (EC50) were 0.205 mg/ml for Nonoxynol-9 and 0.215 mg/ml for chlorhexidine. The implications of these findings in relation to the comparison of the effects of drugs on sperm motility and the development of new contraceptive agents are discussed.
使用客观的跨膜迁移率方法比较了壬苯醇醚-9和洗必泰对精子活力的影响。发现这些药剂在抑制精子活力方面具有相似的效力。使精子活力降低50%（半数有效浓度，EC50）的壬苯醇醚-9浓度为0.205毫克/毫升，洗必泰为0.215毫克/毫升。讨论了这些发现对于比较药物对精子活力的影响以及新型避孕药具开发的意义。
