Chijioke P C, Zaman S, Pearson R M
Contraception. 1986 Aug;34(2):207-11. doi: 10.1016/0010-7824(86)90073-9.
The potency of two new candidate spermicides, d-propranolol and chlorhexidine, was compared with an established agent nonoxynol-9 by the Sander-Cramer test. The lowest concentrations of nonoxynol-9, d-propranolol and chlorhexidine which consistently inhibited progressive forward sperm motility within twenty seconds were found to be 0.12, 0.44, and 4.81 mg/ml, respectively. These relative potencies and other properties of d-propranolol and chlorhexidine indicate that they should be further investigated as alternatives to nonoxynol-9 in spermicidal preparations.
通过桑德-克莱默试验，将两种新型候选杀精剂d-普萘洛尔和氯己定的效力与已有的壬苯醇醚-9进行了比较。结果发现，在20秒内持续抑制精子向前运动的壬苯醇醚-9、d-普萘洛尔和氯己定的最低浓度分别为0.12、0.44和4.81毫克/毫升。d-普萘洛尔和氯己定的这些相对效力及其他特性表明，它们作为杀精制剂中壬苯醇醚-9的替代品应进一步研究。
