Gehrman Philip R, Martin Jennifer L, Shochat Tamar, Nolan Sarah, Corey-Bloom Jody, Ancoli-Israel Sonia
San Diego State Unviersity of California, San Diego Joint Doctoral Program in Clinical Psychology, Brown University of Psychiatry and Human Behavior, San Diego, California 92161, USA.
Am J Geriatr Psychiatry. 2003 Jul-Aug;11(4):426-33.
The authors examined the relationship between sleep-disordered breathing (SDB) and agitation in patients with Alzheimer disease (AD).
Thirty-eight AD patients (29 women, 9 men) in nursing homes in San Diego, CA participated. The mean age was 82.3 years, with a range of 61 to 95 years. Mean Mini-Mental State Exam score was 6.5 (range: 0-16). Sleep was recorded for one night, and agitation was measured with behavioral observations and ratings by nursing staff.
SDB was very prevalent in this sample and was related to some types of agitation during the day but not in the evening or night. Aggressive Agitation on the Cohen-Mansfield Agitation Inventory and Manual Manipulation on the Agitated Behavior Rating Scale were greater with more severe SDB. Searching and wandering agitation decreased with more severe SDB.
This study supports the hypothesis that SDB is related to agitation in AD, although the results are specific to certain types of agitation. Treatment of SDB may decrease agitation, easing the burden of caregiving and prolonging the time that patients are able to remain at home.
作者研究了阿尔茨海默病（AD）患者睡眠呼吸紊乱（SDB）与激越之间的关系。
加利福尼亚州圣地亚哥养老院的38名AD患者（29名女性，9名男性）参与了研究。平均年龄为82.3岁，范围在61至95岁之间。简易精神状态检查表平均得分为6.5（范围：0 - 16）。记录一晚的睡眠情况，并由护理人员通过行为观察和评分来测量激越程度。
SDB在该样本中非常普遍，且与白天的某些激越类型有关，但与傍晚或夜间无关。科恩 - 曼斯菲尔德激越量表上的攻击性行为激越以及激越行为评定量表上的手动操作在SDB越严重时越明显。随着SDB加重，搜寻和徘徊性激越减少。
本研究支持SDB与AD激越相关的假说，尽管结果特定于某些激越类型。治疗SDB可能会减少激越，减轻护理负担并延长患者能够居家的时间。
