通过钯催化氨基连接的卤代乙烯和酮烯醇盐的环化反应合成氮杂环化合物。
Nitrogen heterocycles by palladium-catalyzed cyclization of amino-tethered vinyl halides and ketone enolates.
作者信息
Solé Daniel, Diaba Faïza, Bonjoch Josep
机构信息
Laboratori de Química Orgànica, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, 08028-Barcelona, Spain.
出版信息
J Org Chem. 2003 Jul 11;68(14):5746-9. doi: 10.1021/jo034299q.
PMID:12839475
Abstract
The scope and limitations of Pd(0)-catalyzed intramolecular coupling of amino-tethered vinyl halides and ketone enolates as a methodology for the synthesis of nitrogen heterocycles have been studied. This reaction constitutes a synthetic procedure to obtain bridged, condensed, and monocyclic nitrogen-containing compounds.
摘要
已对钯（0）催化的氨基连接的卤代乙烯与酮烯醇盐的分子内偶联作为合成氮杂环的一种方法的范围和局限性进行了研究。该反应构成了一种获得桥环、稠环和单环含氮化合物的合成方法。
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