Tolstrup Janne Schurmann, Kjaer Susanne Krüger, Holst Claus, Sharif Heidi, Munk Christian, Osler Merete, Schmidt Lone, Andersen Anne-Marie Nybo, Grønbaek Morten
Center for Alcohol Research, National Institute of Public Health, and Institute of Preventive Medicine, Copenhagen Hospital Corporation, Denmark.
Acta Obstet Gynecol Scand. 2003 Aug;82(8):744-9. doi: 10.1034/j.1600-0412.2003.00164.x.
Our aim was to examine the association between use of alcohol and subsequent incidence of primary infertility.
The study subjects were chosen from a population-based cohort of Danish women aged 20-29 years. Eligible women were nulliparous and not pregnant (n = 7760). Information on alcohol intake and potential confounders (age, education, marital status, diseases in the reproductive organs, and cigarette smoking) was assessed at enrollment. The incidence of fertility problems during follow-up was obtained by record linkage with the Danish Hospital Discharge Register and the Danish Infertility Cohort Register. Main outcome measures were hazard ratios of infertility according to alcohol intake at baseline estimated in a multivariate Cox proportional hazards model.
During a mean follow-up of 4.9 years, 368 women had experienced infertility. Alcohol intake at baseline was unassociated with infertility among younger women, but was a significant predictor for infertility among women above age 30. In this age group, the adjusted hazard ratio for consuming seven or more drinks per week was 2.26 (95% confidence interval: 1.19-4.32) compared with women consuming less than one drink per week.
These findings suggest that alcohol intake is a predictor for infertility problems among women in the later reproductive age group.
我们的目的是研究饮酒与原发性不孕后续发生率之间的关联。
研究对象选自丹麦20 - 29岁的基于人群的队列女性。符合条件的女性为未生育且未怀孕者（n = 7760）。在入组时评估饮酒情况及潜在混杂因素（年龄、教育程度、婚姻状况、生殖器官疾病和吸烟情况）。通过与丹麦医院出院登记册和丹麦不孕症队列登记册进行记录链接，获取随访期间生育问题的发生率。主要结局指标是在多变量Cox比例风险模型中根据基线饮酒量估计的不孕风险比。
在平均4.9年的随访期间，368名女性经历了不孕。基线饮酒量与年轻女性的不孕无关，但却是30岁以上女性不孕的显著预测因素。在这个年龄组中，每周饮用七杯或更多酒的女性与每周饮用少于一杯酒的女性相比，调整后的风险比为2.26（95%置信区间：1.19 - 4.32）。
这些发现表明，饮酒是晚育年龄组女性不孕问题的一个预测因素。
