Tavadia S, Bianchi J, Dawe R S, McEvoy M, Wiggins E, Hamill E, Urcelay M, Strong A M M, Douglas W S
Department of Dermatology, Monklands District General Hospital, Lanarkshire, Scotland.
Contact Dermatitis. 2003 May;48(5):261-5. doi: 10.1034/j.1600-0536.2003.00111.x.
Our aim was to determine the frequency and nature of contact sensitivity in venous leg ulcer patients in Lanarkshire. We performed patch testing with the European standard series, antimicrobials and medicaments on 200 patients referred to our leg ulcer clinics. Positive patch tests were found in 136 (68%) patients. Multiple allergies occurred in 102 (51%). The most frequent allergen groups were fragrances (30.5%), antimicrobials (19.5%), topical excipients (19.5%), rubber accelerators (13.5%) and topical corticosteroids (8%). We also found a high prevalence of positive patch tests to Intrasite gel (9.5%) and Hioxyl cream (8.5%), medicaments which are commonly used to treat leg ulcers in our area. Contact sensitivity is common in venous leg ulcer patients and has important implications for patient management. The allergens involved vary depending on local nursing practice. We suggest that all venous leg ulcer patients be patch tested with a locally relevant patch test series.
我们的目的是确定拉纳克郡静脉性腿部溃疡患者接触性敏感的频率和性质。我们对转诊至我们腿部溃疡诊所的200名患者进行了欧洲标准系列、抗菌药物和药物的斑贴试验。136名（68%）患者斑贴试验呈阳性。102名（51%）患者出现多种过敏。最常见的变应原组为香料（30.5%）、抗菌药物（19.5%）、外用辅料（19.5%）、橡胶促进剂（13.5%）和外用皮质类固醇（8%）。我们还发现，对我们地区常用于治疗腿部溃疡的药物Intrasite凝胶（9.5%）和Hioxyl乳膏（8.5%）斑贴试验呈阳性的比例很高。接触性敏感在静脉性腿部溃疡患者中很常见，对患者管理具有重要意义。所涉及的变应原因当地护理实践而异。我们建议对所有静脉性腿部溃疡患者进行与当地相关的斑贴试验系列检测。
