抗逆转录病毒治疗期间出现异常炎症反应的进行性多灶性白质脑病。
Progressive multifocal leucoencephalopathy with unusual inflammatory response during antiretroviral treatment.
作者信息
Hoffmann C, Horst H-A, Albrecht H, Schlote W
机构信息
University of Kiel, Chemnitztrasse 33, 24116 Kiel, Germany.
出版信息
J Neurol Neurosurg Psychiatry. 2003 Aug;74(8):1142-4. doi: 10.1136/jnnp.74.8.1142.
Abstract
A case of biopsy verified progressive multifocal leucoencephalopathy (PML) in an HIV patient is presented. Imaging and histological examination confirmed remarkable inflammatory activity accompanied by an unusually benign clinical course despite no clear evidence of immune reconstitution after the start of antiretroviral treatment. This case not only raises several questions regarding the pathophysiology of PML, but gives also evidence that AIDS associated inflammatory PML must be considered another clinical entity in the expanding range of diseases now commonly referred to as the immune reconstitution syndrome.
摘要
本文报告了一例经活检证实的HIV患者的进行性多灶性白质脑病（PML）病例。影像学和组织学检查证实存在显著的炎症活动，尽管在开始抗逆转录病毒治疗后没有明确的免疫重建证据，但临床病程异常良性。该病例不仅引发了关于PML病理生理学的几个问题，还证明了在现在通常称为免疫重建综合征的不断扩大的疾病范围内，艾滋病相关炎症性PML必须被视为另一种临床实体。
相似文献
1
Progressive multifocal leucoencephalopathy with unusual inflammatory response during antiretroviral treatment.抗逆转录病毒治疗期间出现异常炎症反应的进行性多灶性白质脑病。
J Neurol Neurosurg Psychiatry. 2003 Aug;74(8):1142-4. doi: 10.1136/jnnp.74.8.1142.
2
AIDS presenting as progressive multifocal leukoencephalopathy with clinical response to zidovudine.
Acta Neurol Scand. 1994 Dec;90(6):443-7. doi: 10.1111/j.1600-0404.1994.tb02755.x.
3
4
Progressive multifocal leukoencephalopathy in an HIV-infected child.一名感染艾滋病毒儿童的进行性多灶性白质脑病
Neuroradiology. 1997 Feb;39(2):142-4. doi: 10.1007/s002340050383.
5
Slowly progressive fatal PML-IRIS following antiretroviral initiation at CD4+ nadir of 350 cells/mm despite CD4+ cell count rise to 900 cells/mm.在CD4+细胞最低点为350个细胞/mm³时开始抗逆转录病毒治疗后，尽管CD4+细胞计数升至900个细胞/mm³，但仍出现缓慢进展的致命性进行性多灶性白质脑病合并免疫重建炎症综合征。
Int J STD AIDS. 2019 Jul;30(8):810-813. doi: 10.1177/0956462419835966. Epub 2019 May 2.
6
Inflammatory reaction in progressive multifocal leukoencephalopathy: harmful or beneficial?进行性多灶性白质脑病中的炎症反应：有害还是有益？
J Neurovirol. 2003;9 Suppl 1:25-31. doi: 10.1080/13550280390195315.
7
Inflammatory reactions in progressive multifocal leukoencephalopathy after highly active antiretroviral therapy.高效抗逆转录病毒治疗后进行性多灶性白质脑病中的炎症反应
AIDS. 2001 Sep 28;15(14):1900-2. doi: 10.1097/00002030-200109280-00028.
8
Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable disorder.艾滋病患者中与进行性多灶性白质脑病相关的免疫重建炎症综合征：一种可治疗的疾病。
Neurology. 2006 Nov 14;67(9):1692-4. doi: 10.1212/01.wnl.0000242728.26433.12.
9
Progressive multifocal leukoencephalopathy successfully treated with highly active antiretroviral therapy and cidofovir in an adolescent infected with perinatal human immunodeficiency virus (HIV).一名围产期感染人类免疫缺陷病毒（HIV）的青少年患者，通过高效抗逆转录病毒疗法和西多福韦成功治疗进行性多灶性白质脑病。
J Child Neurol. 2004 Jan;19(1):35-8. doi: 10.1177/088307380401900107011.
10
Progressive multifocal leukoencephalopathy limited to the brain stem.
Neuroradiology. 2002 Mar;44(3):227-9. doi: 10.1007/s00234-001-0714-6.
引用本文的文献
1
MRI Shrimp Sign and Parietooccipital Lesion in Progressive Multifocal Leukoencephalopathy.进行性多灶性白质脑病中的MRI虾征与顶枕叶病变
Cerebellum. 2025 Feb 22;24(2):53. doi: 10.1007/s12311-025-01807-0.
2
Age-Accelerated Increase of White Matter Hyperintensity Volumes Is Exacerbated by Heavy Alcohol Use in People Living With HIV.年龄加速增加的脑白质高信号体积在 HIV 感染者中因重度饮酒而加重。
Biol Psychiatry. 2024 Feb 1;95(3):231-244. doi: 10.1016/j.biopsych.2023.07.023. Epub 2023 Aug 18.
3
Progressive multifocal leukoencephalopathy in a patient with systemic sclerosis treated with methotrexate: A case report and literature review.甲氨蝶呤治疗的系统性硬化症患者发生进行性多灶性白质脑病：一例报告及文献综述
J Scleroderma Relat Disord. 2020 Oct;5(3):NP1-NP6. doi: 10.1177/2397198320926883. Epub 2020 Jun 18.
4
AIDS-related progressive multifocal leukoencephalopathy-really rare in India: A case report and review of literature.艾滋病相关的进行性多灶性白质脑病——在印度真的很罕见：一例病例报告及文献综述
Indian J Sex Transm Dis AIDS. 2018 Jan-Jun;39(1):55-58. doi: 10.4103/ijstd.IJSTD_4_15.
5
Immune Reconstitution Inflammatory Syndrome Unmasking or Worsening AIDS-Related Progressive Multifocal Leukoencephalopathy: A Literature Review.免疫重建炎症综合征揭示或加重艾滋病相关进行性多灶性白质脑病：文献综述
Front Immunol. 2017 May 23;8:577. doi: 10.3389/fimmu.2017.00577. eCollection 2017.
6
Predictors and characteristics of seizures in survivors of progressive multifocal leukoencephalopathy.进行性多灶性白质脑病幸存者癫痫发作的预测因素及特征
J Neurovirol. 2016 Aug;22(4):464-71. doi: 10.1007/s13365-015-0414-3. Epub 2015 Dec 16.
7
Central nervous system diseases due to opportunistic and coinfections.中枢神经系统疾病，由机会性和合并感染引起。
Semin Neurol. 2014 Feb;34(1):61-9. doi: 10.1055/s-0034-1372343. Epub 2014 Apr 8.
8
Encephalitis with infiltration by CD8+ lymphocytes in HIV patients receiving combination antiretroviral treatment.HIV 感染者接受联合抗逆转录病毒治疗后发生 CD8+ 淋巴细胞浸润性脑炎。
Brain Pathol. 2013 Sep;23(5):525-33. doi: 10.1111/bpa.12038. Epub 2013 Mar 18.
9
CNS-immune reconstitution inflammatory syndrome in the setting of HIV infection, part 1: overview and discussion of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome and cryptococcal-immune reconstitution inflammatory syndrome.HIV 感染相关中枢神经系统免疫重建炎性综合征，第 1 部分：概述及进行性多灶性白质脑病-免疫重建炎性综合征和隐球菌性-免疫重建炎性综合征的讨论。
AJNR Am J Neuroradiol. 2013 Jul;34(7):1297-307. doi: 10.3174/ajnr.A3183. Epub 2012 Jul 12.
10
Management of the immune reconstitution inflammatory syndrome.免疫重建炎症综合征的管理。
Curr HIV/AIDS Rep. 2012 Sep;9(3):238-50. doi: 10.1007/s11904-012-0129-5.
Zotero 插件