实验性人类内毒素血症期间心肌肌钙蛋白I的释放及细胞因子反应
Cardiac troponin I release and cytokine response during experimental human endotoxaemia.
作者信息
van Bockel Esther A P, Tulleken Jaap E, Muller Kobold Anneke C, Ligtenberg Jack J M, van der Werf Tjip S, Spanjersberg Rob, Zijlstra Jan G
机构信息
Intensive and Respiratory Care Unit, Department of Internal Medicine, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
出版信息
Intensive Care Med. 2003 Sep;29(9):1598-600. doi: 10.1007/s00134-003-1893-x. Epub 2003 Jul 17.
OBJECTIVE
To study the relationship between cytokine levels and cardiac troponin I (cTnI).
DESIGN
Prospective experimental study.
SETTING
Intensive care unit of a university hospital.
PARTICIPANTS
Six healthy male volunteers. INTERVENTIONS. Endotoxin, 4 ng/kg, was given as a 1-min intravenous infusion.
MEASUREMENTS AND RESULTS
Circulating cardiac troponin I levels and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were analysed at various time points during a 24-h period. TNF-alpha appeared in the circulation 30 min after injection (T=0.5 h), reaching peak levels (5,665+/-1,910 pg/ml) 2 h after infusion. At T=24 h TNF-alpha was still elevated in the circulation compared to T=0. None of the six volunteers had a cTnI value higher than 0.1 microg/l at T=0, 6 h or 24 h.
CONCLUSION
The presence of significant amounts of TNF-alpha, IL-6 and IL-8 in the systemic circulation does not lead to increased levels of cTnI in experimental human endotoxaemia.
目的
研究细胞因子水平与心肌肌钙蛋白I（cTnI）之间的关系。
设计
前瞻性实验研究。
地点
一所大学医院的重症监护病房。
参与者
6名健康男性志愿者。干预措施：以4 ng/kg的剂量静脉注射内毒素1分钟。
测量与结果
在24小时内的不同时间点分析循环心肌肌钙蛋白I水平以及促炎细胞因子肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-8（IL-8）。TNF-α在注射后30分钟（T = 0.5小时）出现在循环中，在输注后2小时达到峰值水平（5,665±1,910 pg/ml）。在T = 24小时时，与T = 0时相比，TNF-α在循环中仍处于升高状态。6名志愿者在T = 0、6小时或24小时时，cTnI值均未高于0.1 μg/l。
结论
在实验性人类内毒素血症中，全身循环中存在大量TNF-α、IL-6和IL-8并不会导致cTnI水平升高。
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