Kumar Maya, Melton Doug
Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Curr Opin Genet Dev. 2003 Aug;13(4):401-7. doi: 10.1016/s0959-437x(03)00089-3.
Much recent investigation has been carried out into the mechanisms by which the pancreas is specified from the early endoderm. Recent advances have highlighted important roles for retinoic acid and bone morphogenetic protein signalling in patterning the endoderm at late gastrulation. Subsequently, interactions with the endothelium of the aorta in the dorsal pancreas domain and lateral plate mesoderm in the ventral pancreas domain are the source of essential pancreas-inductive signals. Additionally, the transcription factor Ptf1a has been demonstrated to have a previously unappreciated role in distinguishing pancreas from surrounding duodenal fates.
最近对胰腺从早期内胚层分化而来的机制进行了大量研究。最近的进展突出了视黄酸和骨形态发生蛋白信号在原肠胚形成后期内胚层模式形成中的重要作用。随后，背侧胰腺区域与主动脉内皮以及腹侧胰腺区域与侧板中胚层之间的相互作用是胰腺诱导必需信号的来源。此外，转录因子Ptf1a已被证明在区分胰腺与周围十二指肠命运方面具有以前未被认识到的作用。
