Kogha Nicholas, Ikubor Joyce Ekeme, Emuoghenerue Ekokidolor Onoriode, Abolodje Efe, Nwajei Ifeanyichukwu Anita, Agboge Raymond Emoefe
Department of Radiology, Delta State University, Oghara, Delta State, Nigeria.
Oman Med J. 2022 Nov 30;37(6):e434. doi: 10.5001/omj.2022.100. eCollection 2022 Nov.
Our study sought to determine the effect of age, parity, body mass index (BMI), and previous oral contraceptive use on gallbladder volume and ejection fraction in pregnancy to enable obstetricians to identify patients at risk of gallbladder disease in pregnancy.
We conducted a prospective cross-sectional study involving 190 pregnant women who were evaluated within 32 and 40 weeks gestation at the Fetal Assessment Unit of the Department of Radiology, University of Ilorin Teaching Hospital, Nigeria. Patients were scanned with a commercially available Ultrasound scanner using a curvilinear probe and a transducer frequency of 3.5 MHz. The fasting gallbladder volume (FGBV) and 30 minutes postprandial gallbladder volume (PGBV) were calculated using the prolate ellipsoid method. Gallbladder ejection fraction was determined using FGBV and PGBV. Each patient's biodata, medical history, and somatometric parameters were documented.
A total of 190 volunteers were included in the study. BMI showed statistically significant positive, though weak correlations with FGBV (r = 0.179, 0.015) and PGBV (r = 0.216, 0.003). Maternal age, parity, and previous oral contraceptive use did not show any statistically significant correlation with gallbladder parameters.
BMI showed a statistically significant but weakly positive correlation with FGBV and PGBV in pregnancy. Our study demonstrated that gallbladder volume in pregnancy might be dependent on BMI. Thus, high BMI may predispose to large gallbladder volume, increasing the risk of biliary stasis and gallstone formation in pregnancy. This is relevant for early detection and prevention of gallbladder disease and follow-up, including expectant management of subjects that may develop gallbladder disease in pregnancy.
我们的研究旨在确定年龄、产次、体重指数（BMI）和既往口服避孕药使用情况对妊娠期胆囊容积和射血分数的影响，以便产科医生识别妊娠期患胆囊疾病风险较高的患者。
我们进行了一项前瞻性横断面研究，纳入了190名孕妇，她们在尼日利亚伊洛林大学教学医院放射科胎儿评估单元于妊娠32至40周内接受评估。使用市售超声扫描仪，配备曲线探头，换能器频率为3.5MHz对患者进行扫描。采用长椭球体法计算空腹胆囊容积（FGBV）和餐后30分钟胆囊容积（PGBV）。利用FGBV和PGBV确定胆囊射血分数。记录每位患者的生物数据、病史和人体测量参数。
共有190名志愿者纳入本研究。BMI与FGBV（r = 0.179，P = 0.015）和PGBV（r = 0.216，P = 0.003）呈统计学显著正相关，不过相关性较弱。产妇年龄、产次和既往口服避孕药使用情况与胆囊参数均无统计学显著相关性。
BMI与妊娠期FGBV和PGBV呈统计学显著但较弱的正相关。我们的研究表明，妊娠期胆囊容积可能取决于BMI。因此，高BMI可能易导致胆囊容积增大，增加妊娠期胆汁淤积和胆结石形成的风险。这对于胆囊疾病的早期检测、预防及随访具有重要意义，包括对妊娠期可能患胆囊疾病的患者进行期待管理。
