Stevenson R D, Gray A C
Clin Exp Immunol. 1976 Dec;26(3):457-62.
Polymorph migration stimulator is a supernatant factor produced by the interaction between glucocorticosteroids and human blood monocytes in culture. Studies on the physical characteristics of this factor show that it is soluble and stable at high and low temperatures. Its activity is reduced by acid and alkali treatment and destroyed by the proteolytic enzyme protease. Experiments involving dialysis, ultrafiltration and Sephadex G-100 gell filtration indicate that the molecular weight of the polymorph migration stimulator is between 12,000 and 15,000. It is suggested that this factor may mediate the anti-inflammatory effects of glucocorticosteroids on phagocytic cells.
多形核白细胞迁移刺激因子是培养过程中糖皮质激素与人血单核细胞相互作用产生的一种上清液因子。对该因子物理特性的研究表明，它可溶且在高低温下均稳定。其活性经酸碱处理会降低，被蛋白水解酶蛋白酶破坏。涉及透析、超滤和葡聚糖凝胶G - 100凝胶过滤的实验表明，多形核白细胞迁移刺激因子的分子量在12,000至15,000之间。提示该因子可能介导糖皮质激素对吞噬细胞的抗炎作用。
