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Studies on the production and action of polymorph migration stimulator.多形核白细胞迁移刺激因子的产生及作用研究。
Clin Exp Immunol. 1976 Jun;24(3):527-33.
2
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Polymorph migration stimulator. A new factor produced by hydrocortisone-treated monocytes.多形核细胞迁移刺激因子。一种由氢化可的松处理过的单核细胞产生的新因子。
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Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids.小胶质细胞中的糖皮质激素和盐皮质激素受体：两种受体介导皮质类固醇的不同作用。
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[Migration and dispersion of T- and B-lymphocytes].
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引用本文的文献

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3
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4
Studies on the physico-chemical characteristics of polymorph migration stimulator.多晶型迁移刺激剂的物理化学特性研究。
Clin Exp Immunol. 1976 Dec;26(3):457-62.

本文引用的文献

1
Delayed hypersensitivity in vitro. III. Effect of cortisone on cytotoxicity of mumps viral antigen.体外迟发型超敏反应。III. 可的松对腮腺炎病毒抗原细胞毒性的影响。
Proc Soc Exp Biol Med. 1958 Jul;98(3):614-7. doi: 10.3181/00379727-98-24124.
2
Biological studies with electrocortin (aldosterone).用电皮质素（醛固酮）进行的生物学研究。
Endocrinology. 1954 Aug;55(2):236-41. doi: 10.1210/endo-55-2-236.
3
Certain biological activities of crystalline electrocortin.结晶电皮质素的某些生物学活性。
Endocrinology. 1954 Aug;55(2):233-6. doi: 10.1210/endo-55-2-233.
4
The inhibition by cortisone of the cytotoxic activity of PPD on tuberculin-hypersensitive cells in tissue culture.可的松对组织培养中结核菌素超敏细胞上PPD细胞毒活性的抑制作用。
J Exp Med. 1952 Dec;96(6):549-54. doi: 10.1084/jem.96.6.549.
5
Human blood monocytes: stimulators of granulocyte and mononuclear colony formation in vitro.人血单核细胞：体外粒细胞和单核细胞集落形成的刺激物。
Science. 1972 Oct 13;178(4057):164-6. doi: 10.1126/science.178.4057.164.
6
Failure of hydrocortisone to inhibit blastogenesis by pokeweed mitogen in human leucocyte cultures.氢化可的松在人白细胞培养物中未能抑制商陆丝裂原诱导的细胞增殖。
Clin Exp Immunol. 1972 Jul;11(3):393-403.
7
Hydrocortisone and the migration of human leucocytes: an indirect effect mediated by mononuclear cells.氢化可的松与人类白细胞的迁移：由单核细胞介导的间接效应。
Clin Exp Immunol. 1973 Jul;14(3):417-26.
8
Polymorph migration stimulator. A new factor produced by hydrocortisone-treated monocytes.多形核细胞迁移刺激因子。一种由氢化可的松处理过的单核细胞产生的新因子。
Clin Exp Immunol. 1974 Aug;17(4):601-6.
9
A simple and efficient method of separating peripheral-blood leucocytes for in-vitro studies.一种用于体外研究的简单高效的分离外周血白细胞的方法。
Lancet. 1967 Jun 17;1(7503):1304-5. doi: 10.1016/s0140-6736(67)91596-6.
10
Role of lymphocyte activation products (LAP) in cell-mediated immunity. I. Preparation and partial purification of guinea-pig LAP.淋巴细胞激活产物（LAP）在细胞介导免疫中的作用。I. 豚鼠LAP的制备及部分纯化
Clin Exp Immunol. 1972 Jan;10(1):25-47.

多形核白细胞迁移刺激因子的产生及作用研究。

Studies on the production and action of polymorph migration stimulator.

作者信息

Stevenson R D

出版信息

Clin Exp Immunol. 1976 Jun;24(3):527-33.

PMID:939053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538519/
Abstract

Human blood monocytes are known to react with hydrocortisone in vitro to produce a factor which stimulates polymorph migration. This study shows that the polymorph migration stimulator (PMS) is generated only by steroids with glucocorticoid activity. The interaction between steroid and monocytes is dependent on protein synthesis. Serum is necessary for the expression of the activity of the factor, but the steroid-monocyte reaction can occur in the absence of serum. The stimulatory effect on migration appears to be specific for polymorphs and does not affect mono-nuclear leucocytes. In addition to blood monocytes, spleen and bone marrow cells also react with corticosteroids to produce the polymorph migration stimulator.

摘要

已知人类血液单核细胞在体外与氢化可的松反应可产生一种刺激多形核白细胞迁移的因子。本研究表明，多形核白细胞迁移刺激因子（PMS）仅由具有糖皮质激素活性的类固醇产生。类固醇与单核细胞之间的相互作用依赖于蛋白质合成。血清对于该因子活性的表达是必需的，但类固醇与单核细胞的反应可在无血清的情况下发生。对迁移的刺激作用似乎对多形核白细胞具有特异性，并不影响单核白细胞。除了血液单核细胞外，脾脏和骨髓细胞也与皮质类固醇反应产生多形核白细胞迁移刺激因子。