De Donno A, Chironna M, Craca R, Paiano A, Zizza A, Guido M, Carrozzini F, Germinario C, Gabutti G
Lab. di Igiene, DiSTeBA, Università degli Studi di Lecce.
Ann Ig. 2003 May-Jun;15(3):199-205.
Hepatitis E virus (HEV) is the causative agent of an enterically transmitted viral hepatitis associated with inadequate hygienic conditions. Hepatitis E is endemic in developing countries where it occurs both in sporadic and epidemic form. Outbreaks have been reported in different areas of the world. The aim of the present work was to assess the seroprevalence of HEV infection in the general population and in different risk groups in the area of Lecce. The presence of anti-HEV antibodies was ascertained by qualitative ELISA (Abbott HEV EIA) and Western Blot (Recomblot HEV IgG/IgM, Mikrogen). The prevalence of anti-HEV in the general population was 2.9% while in intravenous drug users, hemodialized patients and immigrants the seroprevalence rates were 0.7%, 4.3% and 15.3% respectively. Our data show a circulation of HEV at low level in the area of Lecce which is endemic for hepatitis A. Higher seroprevalence rates were found in hemodialized patients and remarkably in immigrants coming from endemic areas like Turkey.
戊型肝炎病毒（HEV）是一种与卫生条件不佳相关的经肠道传播的病毒性肝炎的病原体。戊型肝炎在发展中国家呈地方性流行，以散发和流行形式出现。世界不同地区均有疫情报告。本研究的目的是评估莱切地区普通人群和不同风险人群中戊型肝炎病毒感染的血清流行率。通过定性酶联免疫吸附测定法（雅培戊型肝炎病毒酶免疫测定法）和蛋白质印迹法（重组印迹戊型肝炎病毒IgG/IgM，米克罗根公司）确定抗戊型肝炎病毒抗体的存在。普通人群中抗戊型肝炎病毒的流行率为2.9%，而静脉吸毒者、血液透析患者和移民中的血清流行率分别为0.7%、4.3%和15.3%。我们的数据显示，在甲型肝炎呈地方性流行的莱切地区，戊型肝炎病毒呈低水平传播。血液透析患者中的血清流行率较高，来自土耳其等流行地区的移民中的血清流行率显著更高。
