Machida N, Izumisawa N, Nakamura T, Kiryu K
Department of Veterinary Pathology, Tokyo University of Agriculture and Technology, Japan.
J Comp Pathol. 1992 Nov;107(4):439-43. doi: 10.1016/0021-9975(92)90017-o.
A free-living masked palm civet (Paguma larvata) died after exhibiting signs of canine distemper (CD). The microscopic lesions consisted of cytoplasmic and intranuclear eosinophilic inclusion bodies, bronchointerstitial pneumonia, non-purulent encephalitis accompanied by demyelination and lymphocytic depletion in various lymphoid tissues. CD virus-specific antigens were demonstrated immunohistochemically in intracellular eosinophilic inclusions, which were ultrastructurally confirmed to be viral nucleocapsids. From these findings, the present case was diagnosed as CD virus infection in a masked palm civet.
一只自由放养的果子狸（Paguma larvata）在出现犬瘟热（CD）症状后死亡。显微镜下病变包括细胞质和核内嗜酸性包涵体、支气管间质性肺炎、非化脓性脑炎，伴有各种淋巴组织的脱髓鞘和淋巴细胞减少。通过免疫组织化学在细胞内嗜酸性包涵体中检测到CD病毒特异性抗原，超微结构证实这些包涵体为病毒核衣壳。根据这些发现，本病例被诊断为果子狸感染CD病毒。
