Onalan Gögsen, Pabuçcu Recai, Onalan Reside, Ceylaner Serdar, Selam Belgin
Centrum Clinic, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Ankara, Turkey 06700.
Hum Reprod. 2003 Sep;18(9):1864-7. doi: 10.1093/humrep/deg371.
Empty follicle syndrome (EFS) is characterized by a lack of retrieved oocytes in the presence of multiple follicle development, in both natural and stimulated cycles. The aim of the present case report is to point out the possibility of genetic factors that could be responsible for some occurrences of EFS. Two sisters with moderate deafness underwent controlled ovarian hyperstimulation and IVF/ICSI cycles at the same centre. During all three cycles there were normal follicular development, estradiol levels and bio-available hCG plasma levels, but no oocytes and cumulus-corona complexes were retrieved, despite second hCG injections. These cases may represent an inherited condition of EFS with hearing loss with genetic factors affecting both the aetiology of EFS and the hearing loss.
空卵泡综合征（EFS）的特征是在自然周期和促排卵周期中，尽管有多个卵泡发育，但未检索到卵母细胞。本病例报告的目的是指出遗传因素可能导致某些EFS病例的可能性。两名患有中度耳聋的姐妹在同一中心接受了控制性卵巢过度刺激和IVF/ICSI周期治疗。在所有三个周期中，卵泡发育、雌二醇水平和血浆中生物可利用的hCG水平均正常，但尽管注射了第二次hCG，仍未检索到卵母细胞和卵丘-放射冠复合体。这些病例可能代表一种伴有听力损失的遗传性EFS疾病，遗传因素既影响EFS的病因，也影响听力损失。
