Juhl Mette, Olsen Jørn, Andersen Anne-Marie Nybo, Grønbaek Morten
Danish Epidemiology Science Centre at the Department of Epidemiology Research, Statens Serum Institut, 5 Artillerivej, DK-2300 Copenhagen S, Denmark.
Hum Reprod. 2003 Sep;18(9):1967-71. doi: 10.1093/humrep/deg376.
A high intake of alcohol may prolong waiting time to pregnancy, whereas a moderate intake may have no or perhaps even a positive effect on fecundity. In previous studies on fecundity, different types of beverages have not been taken into consideration, although moderate wine drinkers appear to have fewer strokes, lung and digestive tract cancers, and overall mortality than both abstainers and moderate drinkers of beer or spirits. We examined the association between different types of alcoholic beverages and waiting time to pregnancy.
Self-reported data were used for 29,844 pregnant women, recruited to the Danish National Birth Cohort in 1997-2000. Main outcome measures were odds ratios for a prolonged waiting time to pregnancy according to consumption of wine, beer and spirits.
All levels of wine intake compared with non-wine drinking or with consumption of beer or spirits had subfecundity odds ratios between 0.7 and 0.9. No association was seen regarding beer drinking, while the association with spirits was J-shaped.
Our findings suggest that wine drinkers have slightly shorter waiting times to pregnancy than both non-wine drinkers and consumers of other alcoholic beverages. Whether this is an effect of wine itself or the characteristics of the wine drinker is not known.
高酒精摄入量可能会延长怀孕等待时间,而适度饮酒可能对生育能力没有影响,甚至可能有积极作用。在以往关于生育能力的研究中,尽管适度饮用葡萄酒的人似乎比戒酒者以及适度饮用啤酒或烈酒的人患中风、肺癌和消化道癌症的几率更低,总体死亡率也更低,但并未考虑不同类型的饮料。我们研究了不同类型酒精饮料与怀孕等待时间之间的关联。
使用了1997年至2000年招募到丹麦国家出生队列中的29844名孕妇的自我报告数据。主要结局指标是根据葡萄酒(红酒)、啤酒和烈酒的摄入量计算的怀孕等待时间延长的比值比。
与不饮用葡萄酒或饮用啤酒或烈酒相比,所有葡萄酒摄入量水平的生育力低下比值比在0.7至0.9之间。未发现啤酒饮用与怀孕等待时间之间存在关联,而与烈酒的关联呈J形。
我们的研究结果表明,饮用葡萄酒的人怀孕等待时间比不饮用葡萄酒的人和饮用其他酒精饮料的人略短。这是葡萄酒本身的作用还是饮用葡萄酒者的特征所致尚不清楚。