Lessard Y, Desbrousses S, Paulet G
C R Seances Soc Biol Fil. 1976 Oct;170(3):654-60.
Does difluorodichloromethane (FC 12) sensitize the cardiac muscle in vitro to epinephrine-induced arrhythmia ? We have tried to answer this question by comparing : the action of epinephrine alone on the isolated rabbit heart perfused by an ordinary nutritive solution and the action of epinephrine on the heart perfused by a nutritive solution containing various concentrations of FC 12. The results are: 1) the general action of epinephrine (inotropic and chronotropic positive effects, increase of coronary flow) is not significantly modified by the action of FC 12. 2) FC 12 does not sensitize the rabbit heart in vitro to the arrhythmogenic action of epinephrine. The few cases of arrthymia recorded under the action of adrenalin do not necessarily occur in the presence of FC 12, but rather depend on the weakened state of the preparation.
二氟二氯甲烷（FC 12）在体外会使心肌对肾上腺素诱发的心律失常敏感吗？我们试图通过比较来回答这个问题：单独使用肾上腺素对用普通营养液灌注的离体兔心脏的作用，以及肾上腺素对用含有不同浓度FC 12的营养液灌注的心脏的作用。结果如下：1）肾上腺素的一般作用（正性肌力和正性变时作用，冠状动脉血流量增加）未因FC 12的作用而发生显著改变。2）FC 12在体外不会使兔心脏对肾上腺素的致心律失常作用敏感。在肾上腺素作用下记录到的少数心律失常病例不一定发生在有FC 12存在的情况下，而更取决于标本的衰弱状态。
