Hensten-Pettersen A
NIOM, Scandinavian Institute of Dental Materials, Haslum, Norway.
Adv Dent Res. 1992 Sep;6:38-43. doi: 10.1177/08959374920060011401.
Side-effects from dental materials are a minor problem, but should be recognized. In recent questionnaire surveys about side-effects, the incidence was estimated to be 1:300 in periodontics and 1:2600 in pedodontics. None of these reactions was related to dental casting alloys. In prosthodontics, the incidence was calculated to be about 1:400, and about 27% were related to base-metal alloys for removable partial dentures (cobalt, chromium, nickel) and to noble/gold-based alloys for porcelain-fused-to-metal restorations. The complaints consisted of intra-oral reactions (such as redness, swelling, and pain of the oral mucosa and lips), oral/gingival lichenoid reactions, and a few instances of systemic reactions. In orthodontics, the incidence was 1:100, and most reactions (85%) were related to metal parts of the extra-oral anchorage devices. Even though the extensive use of base-metal alloys has been of major concern to the dental profession, relatively few case reports substantiate this concern. Allergy to gold-based dental restorations has been more commonly reported. Palladium-based alloys have been associated with several cases of stomatitis and oral lichenoid reactions. Palladium allergy seems to occur mainly in patients who are very sensitive to nickel. All casting alloys, except titanium, seem to have a potential for eliciting adverse reactions in individual hypersensitive patients. Tolerance induction may be a possible benefit of the use of intra-orally placed alloys. In non-sensitized individuals, oral antigenic contacts to nickel and chromium may induce tolerance rather than sensitization. A variety of systemic diseases and reactions has been claimed to be caused by dental materials. The claims are generally poorly documented.
牙科材料的副作用是个小问题,但仍应予以重视。在最近有关副作用的问卷调查中,据估计牙周病学中的发生率为1:300,儿童牙科学中的发生率为1:2600。这些反应均与牙科铸造合金无关。在口腔修复学中,发生率约为1:400,约27%与可摘局部义齿的贱金属合金(钴、铬、镍)以及烤瓷熔附金属修复体的贵金属/金基合金有关。投诉包括口腔内反应(如口腔黏膜和嘴唇发红、肿胀及疼痛)、口腔/牙龈苔藓样反应以及少数全身反应。在正畸学中,发生率为1:100,大多数反应(85%)与口外固位装置的金属部件有关。尽管贱金属合金的广泛使用一直是牙科行业主要关注的问题,但相对较少的病例报告证实了这一担忧。对金基牙科修复体过敏的报告更为常见。钯基合金与几例口腔炎和口腔苔藓样反应有关。钯过敏似乎主要发生在对镍非常敏感的患者中。除钛以外的所有铸造合金似乎都有可能在个别过敏患者中引发不良反应。诱导耐受性可能是使用口腔内放置合金的一个潜在益处。在未致敏个体中,口腔与镍和铬的抗原接触可能诱导耐受性而非致敏。人们声称各种全身性疾病和反应是由牙科材料引起的。这些说法通常记录不充分。