作为随机试验中回归变量的依从性评分。
The compliance score as a regressor in randomized trials.
作者信息
Joffe Marshall M, Ten Have Thomas R, Brensinger Colleen
机构信息
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 602 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104-6021, USA.
出版信息
Biostatistics. 2003 Jul;4(3):327-40. doi: 10.1093/biostatistics/4.3.327.
The compliance score in randomized trials is a measure of the effect of randomization on treatment received. It is in principle a group-level pretreatment variable and so can be used where individual-level measures of treatment received can produce misleading inferences. The interpretation of models with the compliance score as a regressor of interest depends on the link function. Using the identity link can lead to valid inference about the effects of treatment received even in the presence of nonrandom noncompliance; such inference is more problematic for nonlinear links. We illustrate these points with data from two randomized trials.
随机试验中的依从性评分是衡量随机化对所接受治疗效果的一种指标。原则上，它是一个组水平的预处理变量，因此当所接受治疗的个体水平测量可能产生误导性推断时，可以使用该指标。将依从性评分作为感兴趣的回归变量的模型解释取决于连接函数。即使存在非随机的不依从情况，使用恒等连接函数也可以对所接受治疗的效果进行有效推断；对于非线性连接函数，这种推断则更具问题。我们用来自两项随机试验的数据来说明这些要点。
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