16S rRNA基因突变对幽门螺杆菌四环素耐药性的影响。
Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori.
作者信息
Gerrits Monique M, Berning Marco, Van Vliet Arnoud H M, Kuipers Ernst J, Kusters Johannes G
机构信息
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
出版信息
Antimicrob Agents Chemother. 2003 Sep;47(9):2984-6. doi: 10.1128/AAC.47.9.2984-2986.2003.
Abstract
The triple-base-pair 16S rDNA mutation AGA(926-928)-->TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.
摘要
三联碱基对16S rDNA突变AGA(926 - 928)-->TTC介导幽门螺杆菌对四环素的高水平耐药。相比之下，单碱基对和双碱基对突变仅介导低水平的四环素耐药，并且在四环素存在的情况下会降低生长速率，这解释了四环素耐药幽门螺杆菌分离株中对TTC突变的偏好。
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