软组织肉瘤的风险与居住在工业废物焚烧炉附近的关系。
Risk of soft tissue sarcomas and residence in the neighbourhood of an incinerator of industrial wastes.
作者信息
Comba P, Ascoli V, Belli S, Benedetti M, Gatti L, Ricci P, Tieghi A
机构信息
National Institute of Health (ISS), Viale Regina Elena 299, 00161 Rome, Italy.
出版信息
Occup Environ Med. 2003 Sep;60(9):680-3. doi: 10.1136/oem.60.9.680.
AIMS
To investigate the association between occurrence of soft tissue sarcomas (STS) in Mantua and residence near an incinerator of industrial wastes.
METHODS
Cases were subjects with histologically confirmed primary malignant STS diagnosed 1989-98 in the population resident in Mantua and in the three neighbouring municipalities. Controls were randomly extracted from population registries, matched for age and sex. Residential history was reconstructed for all study subjects since 1960. Main residence was geographically positioned according to GPS standards.
RESULTS
The study included 37 STS cases (17 men and 20 women) and 171 controls. The incidence of STS in the area of study was estimated as 8.8 per 100 000 in men and 5.6 per 100 000 in women. The odds ratio associated with residence within 2 km, standardised by age and sex, was 31.4 (95% CI 5.6 to 176.1), based on five exposed cases. At greater distances, risk rapidly decreased, showing a fluctuation around the null value of 1.
CONCLUSION
The study shows a significant increase in risk of STS associated with residence within 2 km of an industrial waste incinerator; an aetiological role of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can be hypothesised.
目的
调查曼图亚软组织肉瘤（STS）的发生与工业废物焚烧炉附近居住之间的关联。
方法
病例为1989年至1998年在曼图亚及其三个相邻市镇居住的人群中经组织学确诊的原发性恶性STS患者。对照从人口登记处随机抽取，按年龄和性别匹配。自1960年以来为所有研究对象重建居住史。主要居住地根据全球定位系统标准进行地理定位。
结果
该研究纳入了37例STS病例（17名男性和20名女性）和171名对照。研究区域内STS的发病率估计为男性每10万人中8.8例，女性每10万人中5.6例。基于5例暴露病例，按年龄和性别标准化后，与居住在2公里范围内相关的优势比为31.4（95%可信区间5.6至176.1）。在更大距离处，风险迅速降低，在1的零值附近波动。
结论
该研究表明，居住在工业废物焚烧炉2公里范围内与STS风险显著增加有关；可以假设2,3,7,8 - 四氯二苯并 - 对 - 二恶英（TCDD）具有病因学作用。
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