Angerhofer C K, Pezzuto J M, König G M, Wright A D, Sticher O
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, Chicago 60612.
J Nat Prod. 1992 Dec;55(12):1787-9. doi: 10.1021/np50090a014.
Five sesquiterpenoids containing isonitrile or isothiocyanate groups were isolated from the sponge Acanthella klethra. Compounds 1 and 2 were identified as axisonitrile 3 and the corresponding isothiocyanate derivative, respectively. Compounds 3-5 were found to be eudesmane sesquiterpenes. None of these compounds was cytotoxic toward cultured KB-3 cells, but varying degrees of activity were observed with cultured Plasmodium falciparum. Compound 1 demonstrated greatest promise as an antimalarial agent.
从海绵Acanthella klethra中分离出了五种含有异腈基或异硫氰酸酯基的倍半萜类化合物。化合物1和2分别被鉴定为轴异腈3和相应的异硫氰酸酯衍生物。化合物3 - 5被发现是桉叶烷倍半萜。这些化合物对培养的KB - 3细胞均无细胞毒性，但对培养的恶性疟原虫观察到了不同程度的活性。化合物1作为抗疟剂显示出最大的潜力。
