Ouviña G, Lemberg A, Bengochea L
Cátedra de Fisiopatología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Acta Gastroenterol Latinoam. 1992;22(1):5-8.
The aim of the present study was to determine the effect of bile flow impairment on hepatic lorazepam detoxication and its relationship with the liver microsomal membrane phospholipid composition. It was observed a decrease of phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and sphingomyelin content and an increase of phosphatidylserine and phosphatidylglycerol. A similar activity on lorazepam detoxication was observed when cholestatic rats were compared to controls. These results suggest that there is a different modulation than the phospholipid environment play the key role in lorazepam metabolism, independently of membrane.
本研究的目的是确定胆汁流动受损对肝脏中劳拉西泮解毒作用的影响及其与肝微粒体膜磷脂组成的关系。观察到磷脂酰胆碱、磷脂酰肌醇、磷脂酰乙醇胺和鞘磷脂含量降低，磷脂酰丝氨酸和磷脂酰甘油含量增加。将胆汁淤积大鼠与对照组进行比较时，观察到对劳拉西泮解毒具有类似的活性。这些结果表明，存在一种不同的调节方式，即磷脂环境在劳拉西泮代谢中起关键作用，而与膜无关。
