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本文引用的文献

1
Clinical implications of expression of ETS-1 related to angiogenesis in uterine endometrial cancers.ETS-1表达与子宫内膜癌血管生成的临床意义
Ann Oncol. 2002 Oct;13(10):1605-11. doi: 10.1093/annonc/mdf334.
2
Clinical implications of expression of ETS-1 related to angiogenesis in uterine cervical cancers.ETS-1表达与子宫颈癌血管生成的临床意义
Ann Oncol. 2002 Oct;13(10):1598-604. doi: 10.1093/annonc/mdf248.
3
Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers.血管内皮生长因子在卵巢癌转移病灶中的表达的临床意义
Br J Cancer. 2001 Aug 3;85(3):313-6. doi: 10.1054/bjoc.2001.1933.
4
Ets-1 messenger RNA expression is a novel marker of poor survival in ovarian carcinoma.Ets-1信使核糖核酸表达是卵巢癌患者生存率低的一种新标志物。
Clin Cancer Res. 2001 Mar;7(3):551-7.
5
Immunohistochemical expression of Ets-1 transcription factor and the urokinase-type plasminogen activator is correlated with the malignant and invasive potential in meningiomas.Ets-1转录因子和尿激酶型纤溶酶原激活剂的免疫组化表达与脑膜瘤的恶性和侵袭潜能相关。
Cancer. 2000 Dec 1;89(11):2292-300. doi: 10.1002/1097-0142(20001201)89:11<2292::aid-cncr18>3.0.co;2-0.
6
Involvement of the Ets-1 gene in overexpression of matrilysin in human hepatocellular carcinoma.Ets-1基因在人肝细胞癌中基质溶解素过表达中的作用。
Cancer Res. 2000 Nov 15;60(22):6519-25.
7
Expression of Ets-1 angiogenesis-related protein in gastric cancer.
Cancer Lett. 2000 Nov 10;160(1):45-50. doi: 10.1016/s0304-3835(00)00559-0.
8
Expression and possible role of ets-1 in hepatocellular carcinoma.ets-1在肝细胞癌中的表达及可能作用
Am J Clin Pathol. 2000 Nov;114(5):719-25. doi: 10.1309/RAVV-8NM1-CJB7-GJFR.
9
Expression of ets-1 transcription factor is correlated with penetrating tumor progression in patients with squamous cell carcinoma of the esophagus.
Cancer. 2000 Oct 15;89(8):1670-6. doi: 10.1002/1097-0142(20001015)89:8<1670::aid-cncr4>3.0.co;2-j.
10
Signal transduction and transcriptional regulation of angiogenesis.血管生成的信号转导与转录调控
Adv Exp Med Biol. 2000;476:109-15. doi: 10.1007/978-1-4615-4221-6_9.

ETS-1表达与卵巢癌血管生成的临床意义

Clinical implications of expression of ETS-1 in relation to angiogenesis in ovarian cancers.

作者信息

Khatun Sufia, Fujimoto Jiro, Toyoki Hiroshi, Tamaya Teruhiko

机构信息

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 500-8705, Japan.

出版信息

Cancer Sci. 2003 Sep;94(9):769-73. doi: 10.1111/j.1349-7006.2003.tb01517.x.

DOI:10.1111/j.1349-7006.2003.tb01517.x
PMID:12967474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11160155/
Abstract

ETS-1 has been identified as a transcription factor involved in tumor angiogenesis, which is essential for the growth, invasion, and metastasis of solid tumors. This result prompted us to study whether ETS-1 works as an angiogenic mediator in ovarian cancers. Immunohistochemical staining revealed that ETS-1 was expressed in vascular endothelial cells and in cancer cells of ovarian cancers. There was a significant correlation between microvessel counts and both ETS-1 histoscores and ets-1 mRNA levels in ovarian cancers. Both ETS-1 histoscores and ets-1 mRNA levels increased with the progression of ovarian cancers. Furthermore, the 24-month survival rate of 30 patients with high ets-1 (high ETS-1 histoscores and high ets-1 mRNA levels) was 30%, while that of 30 other patients with low ets-1 (low ETS-1 histoscores and ets-1 mRNA levels) was 70%. There was a significant difference between the 24-month survival rates of the 30 patients with high ets-1 and the 30 with low ets-1. This indicates that ETS-1 might act as an angiogenic mediator in, and be a prognostic factor for, ovarian cancers.

摘要

ETS-1已被确定为一种参与肿瘤血管生成的转录因子，而肿瘤血管生成对于实体瘤的生长、侵袭和转移至关重要。这一结果促使我们研究ETS-1在卵巢癌中是否作为血管生成介质发挥作用。免疫组织化学染色显示，ETS-1在卵巢癌的血管内皮细胞和癌细胞中均有表达。卵巢癌中的微血管计数与ETS-1组织学评分及ets-1 mRNA水平之间存在显著相关性。随着卵巢癌病情进展，ETS-1组织学评分及ets-1 mRNA水平均升高。此外，30例ets-1水平高（ETS-1组织学评分高且ets-1 mRNA水平高）的患者24个月生存率为30%，而另外30例ets-1水平低（ETS-1组织学评分低且ets-1 mRNA水平低）的患者24个月生存率为70%。ets-1水平高的30例患者与ets-1水平低的30例患者的24个月生存率之间存在显著差异。这表明ETS-1可能在卵巢癌中作为血管生成介质发挥作用，并且是卵巢癌的一个预后因素。