Plagemann Peter G W
University of Minnesota, Minneapolis, Minnesota 55455, USA.
Emerg Infect Dis. 2003 Aug;9(8):903-8. doi: 10.3201/eid0908.030232.
Porcine reproductive and respiratory syndrome is a serious swine disease that appeared suddenly in the midwestern United States and central Europe approximately 14 years ago; the disease has now spread worldwide. In North America and Europe, the syndrome is caused by two genotypes of porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus whose genomes diverge by approximately 40%. My hypothesis, which explains the origin and evolution of the two distinct PRRSV genotypes, is that a mutant of a closely related arterivirus of mice (lactate dehydrogenase-elevating virus) infected wild boars in central Europe. These wild boars functioned as intermediate hosts and spread the virus to North Carolina in imported, infected European wild boars in 1912; the virus then evolved independently on the two continents in the prevalent wild hog populations for approximately 70 years until independently entering the domestic pig population.
猪繁殖与呼吸综合征是一种严重的猪病，大约14年前在美国中西部和中欧突然出现；该疾病现已蔓延至全球。在北美和欧洲，该综合征由两种基因型的猪繁殖与呼吸综合征病毒（PRRSV）引起，PRRSV是一种动脉炎病毒，其基因组差异约为40%。我的假设解释了两种不同PRRSV基因型的起源和进化，即小鼠的一种密切相关动脉炎病毒（乳酸脱氢酶升高病毒）的突变体感染了中欧的野猪。这些野猪充当中间宿主，并在1912年通过进口的受感染欧洲野猪将病毒传播到北卡罗来纳州；然后该病毒在两大洲的野生猪种群中独立进化了约70年，直到独立进入家猪种群。
