光暴露诱导的视网膜色素上皮损伤的电生理评估
Electrophysiologic evaluation of retinal pigment epithelial damage induced by photic exposure.
作者信息
Kawano Toshio, Kato Masaru
机构信息
Department of Ophthalmology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan.
出版信息
Retina. 2003 Aug;23(4):513-7. doi: 10.1097/00006982-200308000-00011.
PURPOSE
To evaluate the retinal pigment epithelial damage induced by light exposure.
METHODS
One eye of 20 rabbits was exposed to xenon light for 2 hours at an irradiance of 140 mW/cm2 at the surface of the cornea. The contralateral eye served as a control. Forty-eight hours after the light exposure, corneal direct-coupled electroretinograms and the 7% NaHCO3 (bicarbonate) responses of the standing potential were recorded.
RESULTS
The amplitudes of the a-, b-, and c-waves of the electroretinograms were significantly reduced in the light-exposed eyes, with the c-waves more reduced than the a- and b-waves. The bicarbonate response was also significantly reduced in the irradiated eyes.
CONCLUSIONS
The decrease of the bicarbonate response of the standing potential indicated that significant functional damage of the retinal pigment epithelium was induced by the light exposure.
目的
评估光暴露引起的视网膜色素上皮损伤。
方法
20只兔子的一只眼睛暴露于氙灯下2小时，角膜表面的辐照度为140 mW/cm²。对侧眼作为对照。光暴露48小时后，记录角膜直接耦合视网膜电图和7% NaHCO₃（碳酸氢盐）的静息电位反应。
结果
光暴露眼的视网膜电图a波、b波和c波振幅显著降低，c波降低程度大于a波和b波。照射眼的碳酸氢盐反应也显著降低。
结论
静息电位碳酸氢盐反应降低表明光暴露诱导了视网膜色素上皮的显著功能损伤。
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