[抗生素对土拉弗朗西斯菌的作用]

[Effect of antibiotics on Francisella tularensis].

作者信息

Sidorenko S V, Lebedeva I K, D'iakov S I, Zakharov V A

出版信息

Antibiot Khimioter. 1992 Nov;37(11):14-7.

Abstract

The minimum inhibitory concentrations of rifampicin, doxycycline, sisomicin, ciprofloxacin and phosmidomycin for various strains of Francisella tularensis were 0.5 to 2.0, 0.5 to 2.0, 0.125 to 0.4, 0.625 to 0.125 and 2.0 to 12.5 micrograms/ml, respectively. Ciprofloxacin and sisomicin had a marked bactericidal effect. The bactericidal effect of rifampicin was insignificant. Doxycycline and phomidomycin had practically no such effect. All the antibiotics had a post effect. The level of the post-antibiotic effect was different and depended on the antibiotic concentration.

摘要

利福平、强力霉素、西索米星、环丙沙星和磷霉素对不同菌株土拉弗朗西斯菌的最低抑菌浓度分别为0.5至2.0、0.5至2.0、0.125至0.4、0.625至0.125和2.0至12.5微克/毫升。环丙沙星和西索米星具有显著的杀菌作用。利福平的杀菌作用不明显。强力霉素和磷霉素几乎没有这种作用。所有抗生素都有抗生素后效应。抗生素后效应的水平不同，且取决于抗生素浓度。