抗生素对细胞内土拉热弗朗西斯菌的杀菌活性。
Bactericidal activities of antibiotics against intracellular Francisella tularensis.
作者信息
Maurin M, Mersali N F, Raoult D
机构信息
Unité des Rickettsies, CNRS UPRES A 6020, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille Cedex 05, France.
出版信息
Antimicrob Agents Chemother. 2000 Dec;44(12):3428-31. doi: 10.1128/AAC.44.12.3428-3431.2000.
Abstract
MICs of many antibiotics for Francisella tularensis are low in axenic medium, whereas only aminoglycosides, tetracyclines, and fluoroquinolones are useful in treating tularemic patients. In an in vitro cell system, only these antibiotics, rifampin, and telithromycin were bactericidal against intracellular F. tularensis. These results correlate better with clinical data than MIC data do.
摘要
许多抗生素对土拉弗朗西斯菌在无细胞培养基中的最低抑菌浓度较低，然而只有氨基糖苷类、四环素类和氟喹诺酮类药物对治疗兔热病患者有效。在体外细胞系统中，只有这些抗生素、利福平及泰利霉素对细胞内的土拉弗朗西斯菌具有杀菌作用。这些结果与临床数据的相关性比最低抑菌浓度数据更好。
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