Tsinidou K G, Curzon M E, Sapsford D J
Department of Paediatric Dentistry, University of Leeds, UK.
Int J Paediatr Dent. 1992 Dec;2(3):163-9. doi: 10.1111/j.1365-263x.1992.tb00030.x.
The study compared the effectiveness of temazepam and a mixture of chloral hydrate and hydroxyzine in sedating 20 young children aged 20 to 60 months (mean age 38.7 months). All the children exhibited negative behaviour during a screening visit and required at least two visits for restorative treatment with the use of sedation. The children were assigned randomly to receive either 50 mg/kg of chloral hydrate with 25 mg of hydroxyzine or 0.3 mg/kg of temazepam for the first visit, and the alternate regimen for the second visit, in a double-blind manner. Pulse rate and blood oxygen saturation levels were monitored before, during and after the operative procedures. All the treatment sessions were video-recorded and evaluated independently by three paediatric dentists for the degree of crying, movement, sleep and overall behaviour during specific procedures and at specific time intervals. The results showed no statistically significant differences between the two pharmacologic regimens with regard to crying, movement, sleep and overall behaviour. No significant difference in behaviour was found related to either the order of administration of the drugs or to the sex of the patients. It was concluded that 0.3 mg/kg temazepam and a mixture of 50 mg/kg chloral hydrate with 25 mg hydroxyzine had similar sedative effects on the children receiving dental treatment.
该研究比较了替马西泮与水合氯醛和羟嗪混合物对20名年龄在20至60个月（平均年龄38.7个月）的幼儿进行镇静的效果。所有儿童在筛查就诊期间均表现出消极行为，并且需要至少两次就诊以使用镇静剂进行修复治疗。儿童被随机分配在首次就诊时接受50mg/kg水合氯醛与25mg羟嗪或0.3mg/kg替马西泮，并在第二次就诊时采用交替方案，采用双盲方式。在手术过程之前、期间和之后监测脉搏率和血氧饱和度水平。所有治疗过程均进行视频记录，并由三名儿科牙医独立评估在特定程序和特定时间间隔内的哭闹、活动、睡眠和总体行为程度。结果显示，两种药物治疗方案在哭闹、活动、睡眠和总体行为方面无统计学显著差异。在与药物给药顺序或患者性别相关的行为方面未发现显著差异。得出的结论是，0.3mg/kg替马西泮和50mg/kg水合氯醛与25mg羟嗪的混合物对接受牙科治疗的儿童具有相似的镇静效果。
