Avalos-Arenas V, Moyao-García D, Nava-Ocampo A A, Zayas-Carranza R E, Fragoso-Ríos R
Service of Paediatric Stomatology, Hospital Infantil de México Federico Gómez, Mexico City.
Curr Med Res Opin. 1998;14(4):219-26. doi: 10.1185/03007999809113362.
The primary objective of this study was to evaluate in a random double-blind design, the sedative and behavioural responses of children undergoing outpatient paediatric dental procedures receiving either chloral hydrate (CH) alone or in combination with hydroxyzine. Forty American Society of Anaesthesiologists class I children (21 to 36 months of age) were randomly allocated to receive either 70 mg/kg CH alone or with 2 mg/kg hydroxyzine. The degree of crying, movement and overall behaviour was evaluated during treatment at different times. The combination of chloral hydrate/hydroxyzine (CH/H) significantly decreased crying and movement in relation to the effect induced by CH alone (p < 0.05) only at 45-60 min following the insertion of a rubber dam, whereas the overall behavior in both groups was no different throughout the dental procedures. In conclusion, our study demonstrated that hydroxyzine increased the effect of CH. However, because of the presence of high rates of oxygen desaturations and of deep sedation, careful use of this drug combination should be stressed.
本研究的主要目的是采用随机双盲设计，评估接受水合氯醛（CH）单独使用或与羟嗪联合使用的门诊儿科牙科手术患儿的镇静和行为反应。40名美国麻醉医师协会I级儿童（21至36个月大）被随机分配接受单独70mg/kg的CH或与2mg/kg羟嗪联合使用。在治疗期间的不同时间评估哭闹、活动和总体行为的程度。仅在放置橡皮障后45 - 60分钟时，水合氯醛/羟嗪（CH/H）组合相对于单独使用CH引起的效果，显著减少了哭闹和活动（p < 0.05），而在整个牙科手术过程中两组的总体行为并无差异。总之，我们的研究表明羟嗪增强了CH的效果。然而，由于存在高比例的氧饱和度降低和深度镇静情况，应强调谨慎使用这种药物组合。
