COFFIN D L, COONS A H, CABASSO V J
J Exp Med. 1953 Jul;98(1):13-20. doi: 10.1084/jem.98.1.13.
A study of experimental infectious canine hepatitis in dogs by means of specific fluorescent antibody indicates that the intranuclear inclusions of this disease contain high concentrations of viral antigen. The increase in virus in the nuclei, as indicated by the accumulation of specific antigenic material, begins on the nuclear membrane and spreads from there to the interior of the nucleus, with the gradual formation of larger granules. Subsequently there appear the homogeneous inclusion bodies characteristic of this infection.
一项通过特异性荧光抗体对犬实验性传染性肝炎的研究表明，该疾病的核内包涵体含有高浓度的病毒抗原。如特异性抗原物质的积累所示，细胞核内病毒的增加始于核膜，并从那里扩散到细胞核内部，逐渐形成更大的颗粒。随后出现了这种感染特有的均匀包涵体。
