姜黄素可抑制亚硝酸盐诱导的高铁血红蛋白形成。
Curcumin inhibits nitrite-induced methemoglobin formation.
作者信息
Unnikrishnan M K, Rao M N
机构信息
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
出版信息
FEBS Lett. 1992 Apr 20;301(2):195-6. doi: 10.1016/0014-5793(92)81246-i.
PMID:1314741
Abstract
Curcumin protects hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when curcumin is added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of curcumin to scavenge superoxide may be responsible since superoxide is implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite.
摘要
姜黄素可保护血红蛋白不被亚硝酸盐诱导氧化为高铁血红蛋白。当在亚硝酸盐氧化血红蛋白的自催化阶段之后添加姜黄素时，这种保护作用未被观察到。姜黄素清除超氧阴离子的能力可能起了作用，因为超氧阴离子与促进亚硝酸盐氧化血红蛋白的自催化阶段有关。
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