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相似文献

1
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶与抗人类免疫缺陷病毒或抗癌核苷的体外药物联合应用
Antimicrob Agents Chemother. 1992 Jan;36(1):214-6. doi: 10.1128/AAC.36.1.214.
2
Strains of varicella-zoster virus resistant to 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil.对1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶耐药的水痘-带状疱疹病毒毒株
Antimicrob Agents Chemother. 1984 Jun;25(6):742-6. doi: 10.1128/AAC.25.6.742.
3
Antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against thymidine kinase negative strains of varicella-zoster virus.1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶对水痘-带状疱疹病毒胸苷激酶阴性株的抗病毒活性。
Microbiol Immunol. 1993;37(11):877-82. doi: 10.1111/j.1348-0421.1993.tb01719.x.
4
Mechanism of selective inhibition of varicella zoster virus replication by 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil.1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶对水痘带状疱疹病毒复制的选择性抑制机制
Mol Pharmacol. 1989 Aug;36(2):312-6.
5
Antiviral potencies of BV-araU and related nucleoside analogues against varicella-zoster virus in different cell lines.BV-araU及相关核苷类似物在不同细胞系中对水痘-带状疱疹病毒的抗病毒效力
Microbiol Immunol. 1990;34(11):959-65. doi: 10.1111/j.1348-0421.1990.tb01074.x.
6
Oral bioavailability and anti-simian varicella virus efficacy of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) in monkeys.1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶（BV-araU）在猴体内的口服生物利用度及抗猴水痘病毒疗效
J Infect Dis. 1992 Apr;165(4):732-6. doi: 10.1093/infdis/165.4.732.
7
Comparison of two bromovinyl nucleoside analogs, 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and E-5-(2-bromovinyl)-2'-deoxyuridine, with acyclovir in inhibition of Epstein-Barr virus replication.两种溴乙烯基核苷类似物，即1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶和E-5-(2-溴乙烯基)-2'-脱氧尿苷，与阿昔洛韦在抑制爱泼斯坦-巴尔病毒复制方面的比较。
Antimicrob Agents Chemother. 1988 Jul;32(7):1068-72. doi: 10.1128/AAC.32.7.1068.
8
In vitro and in vivo antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and related compounds.1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶（BV-araU）及相关化合物的体外和体内抗病毒活性
Antiviral Res. 1984 Jun;4(3):135-41. doi: 10.1016/0166-3542(84)90013-5.
9
Effects of various nucleosides on antiviral activity and metabolism of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against herpes simplex virus types 1 and 2.各种核苷对1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶抗1型和2型单纯疱疹病毒的抗病毒活性及代谢的影响。
Antimicrob Agents Chemother. 1988 Oct;32(10):1547-51. doi: 10.1128/AAC.32.10.1547.
10
Manual and automated determination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and its metabolite (E)-5-(2-bromovinyl)uracil in urine.尿液中1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶及其代谢物(E)-5-(2-溴乙烯基)尿嘧啶的手动和自动测定
J Chromatogr B Biomed Appl. 1995 Feb 17;664(2):357-63. doi: 10.1016/0378-4347(94)00487-p.

本文引用的文献

1
Antiherpesviral and anticellular effects of 1-beta-D-arabinofuranosyl-E-5-(2-halogenovinyl) uracils.1-β-D-阿拉伯呋喃糖基-E-5-(2-卤代乙烯基)尿嘧啶的抗疱疹病毒及抗细胞作用
Antimicrob Agents Chemother. 1981 Jul;20(1):47-52. doi: 10.1128/AAC.20.1.47.
2
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.（E）-5-（2-溴乙烯基）尿嘧啶对大鼠和白血病小鼠体内5-氟尿嘧啶分解代谢及抗肿瘤活性的影响。
Cancer Res. 1986 Mar;46(3):1094-101.
3
Herpes zoster in African patients: a clinical predictor of human immunodeficiency virus infection.非洲患者的带状疱疹：人类免疫缺陷病毒感染的临床预测指标
J Infect Dis. 1988 Feb;157(2):314-8. doi: 10.1093/infdis/157.2.314.
4
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus.2',3'-二脱氢-2',3'-二脱氧核苷对人类免疫缺陷病毒的感染性、细胞病变效应及复制的抑制作用
Antimicrob Agents Chemother. 1987 Jun;31(6):907-10. doi: 10.1128/AAC.31.6.907.
5
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.2',3'-双脱氧胸苷及其2',3'-不饱和衍生物（2',3'-双脱氧胸苷烯）在体外都是人类免疫缺陷病毒复制的强效和选择性抑制剂。
Biochem Biophys Res Commun. 1987 Jan 15;142(1):128-34. doi: 10.1016/0006-291x(87)90460-8.
6
Comparison of susceptibilities of varicella-zoster virus and herpes simplex viruses to nucleoside analogs.水痘带状疱疹病毒和单纯疱疹病毒对核苷类似物的敏感性比较。
Antimicrob Agents Chemother. 1986 Mar;29(3):524-6. doi: 10.1128/AAC.29.3.524.
7
Effects of various nucleosides on antiviral activity and metabolism of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against herpes simplex virus types 1 and 2.各种核苷对1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶抗1型和2型单纯疱疹病毒的抗病毒活性及代谢的影响。
Antimicrob Agents Chemother. 1988 Oct;32(10):1547-51. doi: 10.1128/AAC.32.10.1547.
8
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.用于检测抗HIV化合物的基于四氮唑的快速自动化比色测定法。
J Virol Methods. 1988 Aug;20(4):309-21. doi: 10.1016/0166-0934(88)90134-6.
9
Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus.
Biochem Pharmacol. 1987 Sep 1;36(17):2713-8. doi: 10.1016/0006-2952(87)90253-x.
10
A double-blind clinical study in patients with herpes zoster to establish YN-72 (Brovavir) dose.一项针对带状疱疹患者的双盲临床研究，以确定YN-72（溴夫定）的剂量。
Adv Exp Med Biol. 1990;278:267-75. doi: 10.1007/978-1-4684-5853-4_27.

1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶与抗人类免疫缺陷病毒或抗癌核苷的体外药物联合应用

In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.

作者信息

Machida H, Ashida N, Ikeda T, Sakata S, Baba M, Shigeta S

机构信息

Biology Laboratory, Yamasa Shoyu Co., Ltd., Choshi, Japan.

出版信息

Antimicrob Agents Chemother. 1992 Jan;36(1):214-6. doi: 10.1128/AAC.36.1.214.

DOI:10.1128/AAC.36.1.214
PMID:1317147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189263/
Abstract

1-beta-D-Arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and E-5-(2-bromovinyl)uracil, a metabolite of BV-araU, did not affect either the anti-human immunodeficiency virus activity or the cytotoxicity of azidothymidine in MT-4 and MOLT-4 cells. Similarly, the bromovinyl compounds did not affect the in vitro antitumor activities of arabinosylcytosine, 5-fluorouracil, and 5-fluoro-2'-deoxyuridine. The anti-varicella-zoster virus activity of BV-araU was not influenced by azidothymidine, 2',3'-didehydro-2',3'-dideoxythymidine, or arabinosylcytosine, whereas relatively high concentrations of fluorinated antitumor agents enhanced the anti-varicella-zoster virus activity.

摘要

1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶（BV-araU）及其代谢产物E-5-(2-溴乙烯基)尿嘧啶对MT-4和MOLT-4细胞中叠氮胸苷的抗人免疫缺陷病毒活性和细胞毒性均无影响。同样，溴乙烯基化合物对阿糖胞苷、5-氟尿嘧啶和5-氟-2'-脱氧尿苷的体外抗肿瘤活性也无影响。BV-araU的抗水痘带状疱疹病毒活性不受叠氮胸苷、2',3'-二脱氢-2',3'-二脱氧胸苷或阿糖胞苷的影响，而相对高浓度的氟化抗肿瘤药物可增强其抗水痘带状疱疹病毒活性。