1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶与抗人类免疫缺陷病毒或抗癌核苷的体外药物联合应用
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.
作者信息
Machida H, Ashida N, Ikeda T, Sakata S, Baba M, Shigeta S
机构信息
Biology Laboratory, Yamasa Shoyu Co., Ltd., Choshi, Japan.
出版信息
Antimicrob Agents Chemother. 1992 Jan;36(1):214-6. doi: 10.1128/AAC.36.1.214.
Abstract
1-beta-D-Arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and E-5-(2-bromovinyl)uracil, a metabolite of BV-araU, did not affect either the anti-human immunodeficiency virus activity or the cytotoxicity of azidothymidine in MT-4 and MOLT-4 cells. Similarly, the bromovinyl compounds did not affect the in vitro antitumor activities of arabinosylcytosine, 5-fluorouracil, and 5-fluoro-2'-deoxyuridine. The anti-varicella-zoster virus activity of BV-araU was not influenced by azidothymidine, 2',3'-didehydro-2',3'-dideoxythymidine, or arabinosylcytosine, whereas relatively high concentrations of fluorinated antitumor agents enhanced the anti-varicella-zoster virus activity.
摘要
1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶（BV-araU）及其代谢产物E-5-(2-溴乙烯基)尿嘧啶对MT-4和MOLT-4细胞中叠氮胸苷的抗人免疫缺陷病毒活性和细胞毒性均无影响。同样，溴乙烯基化合物对阿糖胞苷、5-氟尿嘧啶和5-氟-2'-脱氧尿苷的体外抗肿瘤活性也无影响。BV-araU的抗水痘带状疱疹病毒活性不受叠氮胸苷、2',3'-二脱氢-2',3'-二脱氧胸苷或阿糖胞苷的影响，而相对高浓度的氟化抗肿瘤药物可增强其抗水痘带状疱疹病毒活性。
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本文引用的文献
1
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Antimicrob Agents Chemother. 1981 Jul;20(1):47-52. doi: 10.1128/AAC.20.1.47.
2
3
Herpes zoster in African patients: a clinical predictor of human immunodeficiency virus infection.非洲患者的带状疱疹：人类免疫缺陷病毒感染的临床预测指标
J Infect Dis. 1988 Feb;157(2):314-8. doi: 10.1093/infdis/157.2.314.
4
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus.2',3'-二脱氢-2',3'-二脱氧核苷对人类免疫缺陷病毒的感染性、细胞病变效应及复制的抑制作用
Antimicrob Agents Chemother. 1987 Jun;31(6):907-10. doi: 10.1128/AAC.31.6.907.
5
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Biochem Biophys Res Commun. 1987 Jan 15;142(1):128-34. doi: 10.1016/0006-291x(87)90460-8.
6
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7
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