致糖尿病药物引起的胰岛细胞膜改变。
Islet cell membrane alteration by diabetogenic drugs.
作者信息
Orci L, Amherdt M, Malaisse-Lagae F, Ravazzola M, Malaisse W J, Perrelet A, Renold A E
出版信息
Lab Invest. 1976 May;34(5):451-4.
PMID:131879
Abstract
Freeze-fracture of islets of Langerhans treated in vitro with diabetogenic agents alloxan and streptozotocin shows a decrease in the number of intramembranous particles of islet cell plasma membranes. This decrease is restricted to the membrane's A-fracture face and it can be prevented by experimental conditions which are known to counteract the toxic effect of both alloxan and streptozotocin.
摘要
用致糖尿病药物四氧嘧啶和链脲佐菌素在体外处理的胰岛进行冷冻断裂，结果显示胰岛细胞质膜内的膜内颗粒数量减少。这种减少仅限于膜的A面断裂面，并且可以通过已知能抵消四氧嘧啶和链脲佐菌素毒性作用的实验条件来预防。
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