鼻咽癌患者对EB病毒的长期T细胞免疫受损。
Impaired long-term T cell immunity to Epstein-Barr virus in patients with nasopharyngeal carcinoma.
作者信息
Tamura S, Yamazaki A, Kunimoto M, Takemura K, Tabata T, Hinuma Y, Yoshie O
机构信息
Shionogi Institute for Medical Science, Osaka.
出版信息
Jpn J Cancer Res. 1992 May;83(5):445-9. doi: 10.1111/j.1349-7006.1992.tb01948.x.
Abstract
The long-term T cell immunity to Epstein-Barr virus (EBV) is considered to play an important role in suppressing proliferation of EBV-infected B cells and outgrowth of EBV-associated tumors. It can be manifested and quantified by the EBV-induced focus regression assay. In the present study, we examined the strength of T cell immunity to EBV in patients with nasopharyngeal carcinoma (NPC) and other cancers originating from the head and neck region. In contrast to patients with other types of cancers, including EBV-negative NPC, patients with EBV-positive NPC were found to have a profound impairment in the long-term T cell immunity to EBV.
摘要
长期以来，针对爱泼斯坦-巴尔病毒（EBV）的T细胞免疫被认为在抑制EBV感染的B细胞增殖以及EBV相关肿瘤的生长中发挥重要作用。它可以通过EBV诱导的病灶消退试验来体现和量化。在本研究中，我们检测了鼻咽癌（NPC）患者以及其他头颈部原发癌症患者针对EBV的T细胞免疫强度。与包括EBV阴性NPC在内的其他类型癌症患者相比，EBV阳性NPC患者被发现针对EBV的长期T细胞免疫存在严重缺陷。
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