Pedneault L, Katz B Z, Miller G
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510.
Ann Neurol. 1992 Aug;32(2):184-92. doi: 10.1002/ana.410320210.
Epstein-Barr virus (EBV) has been implicated in a variety of central nervous system syndromes. In a few well-studied patients, EBV has been detected by viral isolation or EBV DNA has been found by Southern hybridization analysis. Using polymerase chain reaction, we evaluated brain biopsy specimens from 24 patients for the presence of EBV genomes. EBV DNA was found in brain specimens from 18 patients in whom presence of the virus in the brain was suspected clinically or on the basis of serological tests. Six patients had acquired immunodeficiency syndrome; 2 were kidney transplant recipients. Brain specimens from 4 patients with encephalitis due to other herpes group viruses and from a patient with metabolic encephalopathy were negative for EBV DNA as determined by polymerase chain reaction. The findings indicate a need to evaluate the role of EBV in diverse neurological syndromes, especially those occurring in immunodeficient hosts.
爱泼斯坦-巴尔病毒（EBV）已被认为与多种中枢神经系统综合征有关。在一些经过充分研究的患者中，通过病毒分离检测到了EBV，或者通过Southern杂交分析发现了EBV DNA。我们使用聚合酶链反应评估了24例患者脑活检标本中EBV基因组的存在情况。在临床上或根据血清学检测怀疑脑内存在该病毒的18例患者的脑标本中发现了EBV DNA。6例患者患有获得性免疫缺陷综合征；2例为肾移植受者。通过聚合酶链反应测定，4例因其他疱疹病毒组病毒引起脑炎的患者以及1例患有代谢性脑病患者的脑标本中EBV DNA呈阴性。这些发现表明有必要评估EBV在多种神经综合征中的作用，尤其是在免疫缺陷宿主中发生的综合征。
