喷昔洛韦和阿昔洛韦对1型和2型单纯疱疹病毒的体外活性
In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2.
作者信息
Weinberg A, Bate B J, Masters H B, Schneider S A, Clark J C, Wren C G, Allaman J A, Levin M J
机构信息
Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver 80262.
出版信息
Antimicrob Agents Chemother. 1992 Sep;36(9):2037-8. doi: 10.1128/AAC.36.9.2037.
Abstract
Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-fold less HSV than acyclovir-treated cultures, consistent with the prolonged intracellular half-life of PCV triphosphate.
摘要
喷昔洛韦（PCV）和阿昔洛韦是无环鸟嘌呤类似物，可抑制单纯疱疹病毒（HSV）DNA聚合酶。对于HSV-1临床分离株，其50%感染剂量为0.5至0.8微克/毫升，对于HSV-2则为1.3至2.2微克/毫升。此外，接受2小时喷昔洛韦脉冲处理的HSV感染培养物中的HSV比接受阿昔洛韦处理的培养物少2至50倍，这与喷昔洛韦三磷酸酯延长的细胞内半衰期一致。
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