Rothe J, Gehr G, Loetscher H, Lesslauer W
F. Hoffmann-La Roche, Ltd., Basel, Switzerland.
Immunol Res. 1992;11(2):81-90. doi: 10.1007/BF02918612.
Tumor necrosis factors (TNFs) have been a focus of research for well over a decade now. The identification and recent molecular cloning of two different types of cell-surface TNF receptors will shed further light on the mode of action of these pleiotropic cytokines. In the present article, we summarize the data on the biochemistry and structure of the receptors and focus on the molecular cloning of the respective cDNAs. The nucleotide sequences of the receptor genes revealed that both TNF receptors belong to the still growing nerve growth factor receptor gene family. The function and origin of TNF inhibitory proteins as well as receptor-mediated signal transduction are discussed.
肿瘤坏死因子（TNFs）已经成为十多年来的研究焦点。两种不同类型的细胞表面TNF受体的鉴定及近期的分子克隆将进一步阐明这些多效性细胞因子的作用方式。在本文中，我们总结了关于这些受体的生物化学和结构的数据，并着重于各自cDNA的分子克隆。受体基因的核苷酸序列显示，两种TNF受体都属于仍在不断增加的神经生长因子受体基因家族。本文还讨论了TNF抑制蛋白的功能和来源以及受体介导的信号转导。
