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一种人肿瘤坏死因子α抑制剂。

A human inhibitor of tumor necrosis factor alpha.

作者信息

Seckinger P, Isaaz S, Dayer J M

机构信息

Department of Medicine, University Hospital, Geneva, Switzerland.

出版信息

J Exp Med. 1988 Apr 1;167(4):1511-6. doi: 10.1084/jem.167.4.1511.

DOI:10.1084/jem.167.4.1511
PMID:2833558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188924/
Abstract

Urine of some febrile patients exhibits a TNF-alpha inhibitory activity (TNF-alpha INH), sensitive to heat and trypsin, with an apparent mol wt of 40-60 X 10(3) and a pI range of 5.5-6.1. As for the Il-1 INH, the TNF INH activity involves a competitive mechanism of action suggesting the existence of a family of negative feedback-regulating molecules interfering with cytokines actions.

摘要

一些发热患者的尿液表现出对热和胰蛋白酶敏感的肿瘤坏死因子-α抑制活性（TNF-α INH），其表观分子量为40 - 60×10³，等电点范围为5.5 - 6.1。至于白细胞介素-1抑制物（Il-1 INH），TNF抑制活性涉及一种竞争性作用机制，提示存在一族干扰细胞因子作用的负反馈调节分子。

相似文献

1
A human inhibitor of tumor necrosis factor alpha.一种人肿瘤坏死因子α抑制剂。
J Exp Med. 1988 Apr 1;167(4):1511-6. doi: 10.1084/jem.167.4.1511.
2
Characterization of a tumor necrosis factor alpha (TNF-alpha) inhibitor: evidence of immunological cross-reactivity with the TNF receptor.一种肿瘤坏死因子α（TNF-α）抑制剂的特性：与TNF受体免疫交叉反应性的证据。
Proc Natl Acad Sci U S A. 1990 Jul;87(13):5188-92. doi: 10.1073/pnas.87.13.5188.
3
Purification and biologic characterization of a specific tumor necrosis factor alpha inhibitor.一种特异性肿瘤坏死因子α抑制剂的纯化及生物学特性分析
J Biol Chem. 1989 Jul 15;264(20):11966-73.
4
A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha.白细胞介素1活性的一种尿液抑制剂对白细胞介素1α和1β均有影响，但对肿瘤坏死因子α无影响。
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5
Tumor necrosis factor inhibitor: purification, NH2-terminal amino acid sequence and evidence for anti-inflammatory and immunomodulatory activities.肿瘤坏死因子抑制剂：纯化、氨基末端氨基酸序列及抗炎和免疫调节活性的证据
Eur J Immunol. 1990 May;20(5):1167-74. doi: 10.1002/eji.1830200533.
6
TNF inhibitor with a low molecular weight found in the human sera.在人血清中发现的低分子量肿瘤坏死因子抑制剂。
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7
A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.第二种肿瘤坏死因子受体基因产物可释放一种天然存在的肿瘤坏死因子抑制剂。
Proc Natl Acad Sci U S A. 1990 Nov;87(21):8331-5. doi: 10.1073/pnas.87.21.8331.
8
Identification of tumor necrosis factor and lymphotoxin blocking factor(s) in the ascites of patients with advanced and recurrent ovarian cancer.晚期复发性卵巢癌患者腹水中肿瘤坏死因子和淋巴毒素阻断因子的鉴定。
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Inhibition of tumour necrosis factor alpha (TNF-alpha)-induced neutrophil respiratory burst by a TNF inhibitor.一种肿瘤坏死因子抑制剂对肿瘤坏死因子α（TNF-α）诱导的中性粒细胞呼吸爆发的抑制作用。
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Pediatr Res. 1993 Apr;33(4 Pt 1):380-3. doi: 10.1203/00006450-199304000-00013.

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本文引用的文献

1
Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta.白细胞介素2、γ干扰素和丝裂原对肿瘤坏死因子α和β产生的影响。
J Immunol. 1985 Oct;135(4):2492-7.
2
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.肿瘤坏死因子（恶病质素）是一种内源性热原，可诱导白细胞介素1的产生。
J Exp Med. 1986 Jun 1;163(6):1433-50. doi: 10.1084/jem.163.6.1433.
3
A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha.白细胞介素1活性的一种尿液抑制剂对白细胞介素1α和1β均有影响，但对肿瘤坏死因子α无影响。
J Immunol. 1987 Sep 1;139(5):1541-5.
4
Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.肿瘤坏死因子和白细胞介素1：具有多种重叠生物学活性的细胞因子。
Lab Invest. 1987 Mar;56(3):234-48.
5
Prostaglandin E2 and collagenase production by fibroblasts and synovial cells is regulated by urine-derived human interleukin 1 and inhibitor(s).成纤维细胞和滑膜细胞产生前列腺素E2和胶原酶受尿源人白细胞介素1及抑制剂调控。
J Clin Invest. 1986 Oct;78(4):1120-4. doi: 10.1172/JCI112669.
6
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.恶病质素/肿瘤坏死因子可刺激人滑膜细胞和真皮成纤维细胞产生胶原酶和前列腺素E2。
J Exp Med. 1985 Dec 1;162(6):2163-8. doi: 10.1084/jem.162.6.2163.
7
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin.肿瘤坏死因子与巨噬细胞分泌因子恶病质素的同一性。
Nature. 1985;316(6028):552-4. doi: 10.1038/316552a0.
8
Interleukin-1 inhibitors.白细胞介素-1抑制剂
Ann Inst Pasteur Immunol. 1987 May-Jun;138(3):486-8. doi: 10.1016/s0769-2625(87)80063-6.
9
A urine inhibitor of interleukin 1 activity that blocks ligand binding.一种可阻断配体结合的白细胞介素1活性的尿液抑制剂。
J Immunol. 1987 Sep 1;139(5):1546-9.
10
An endotoxin-induced serum factor that causes necrosis of tumors.一种由内毒素诱导产生的、可导致肿瘤坏死的血清因子。
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70. doi: 10.1073/pnas.72.9.3666.