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Rapid screening for resistance to ganciclovir and foscarnet of primary isolates of human cytomegalovirus from culture-positive blood samples.对培养阳性血样中分离出的人巨细胞病毒原始菌株进行更昔洛韦和膦甲酸钠耐药性快速筛查。
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9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.9 -（[2 - 羟基 - 1 -（羟甲基）乙氧基]甲基）鸟嘌呤：一种疱疹病毒组复制的选择性抑制剂。
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Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.9-[(1,3-二羟基-2-丙氧基)甲基]鸟嘌呤对疱疹病毒的独特体外活性谱及其对1型单纯疱疹病毒的作用方式
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Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferons.9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤单独及与人干扰素联合使用对人巨细胞病毒复制的抑制作用
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High-performance liquid chromatographic method for the determination of 9-(1,3-dihydroxy-2-propoxymethyl)guanine in human plasma.高效液相色谱法测定人血浆中9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤
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In vitro susceptibility of cytomegalovirus isolates from immunocompromised patients to acyclovir and ganciclovir.
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6
A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate.一种对核苷类似物9-([2-羟基-1-(羟甲基)乙氧基]甲基)鸟嘌呤（BW B759U）耐药的人巨细胞病毒突变体诱导产生的BW B759U三磷酸水平降低。
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Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses.9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤与阿昔洛韦对人、猴和啮齿动物巨细胞病毒的活性比较。
Antimicrob Agents Chemother. 1985 Aug;28(2):240-5. doi: 10.1128/AAC.28.2.240.
8
Sensitivity of clinical isolates of human cytomegalovirus to 9-(1,3-dihydroxy-2-propoxymethyl)guanine.人巨细胞病毒临床分离株对9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤的敏感性
J Infect Dis. 1985 Oct;152(4):833-4. doi: 10.1093/infdis/152.4.833.
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Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients.
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Rapid antiviral DNA-DNA hybridization assay for human cytomegalovirus.用于人类巨细胞病毒的快速抗病毒DNA-DNA杂交检测法。
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直接从临床标本原代培养物中快速测定人巨细胞病毒对更昔洛韦的敏感性。

Rapid determination of human cytomegalovirus susceptibility to ganciclovir directly from clinical specimen primocultures.

作者信息

Pepin J M, Simon F, Dussault A, Collin G, Dazza M C, Brun-Vezinet F

机构信息

Department of Virology, Claude Bernard Hospital, Paris, France.

出版信息

J Clin Microbiol. 1992 Nov;30(11):2917-20. doi: 10.1128/jcm.30.11.2917-2920.1992.

DOI:10.1128/jcm.30.11.2917-2920.1992
PMID:1333484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC270552/
Abstract

We were able to rapidly determine the susceptibility of human cytomegalovirus to ganciclovir using a late antigen synthesis reduction assay directly on primocultures of clinical specimens. This test was compared with a conventional susceptibility assay which was performed with cell-free virus obtained after cytomegalovirus isolation and in vitro passages. Both tests produced similar results. The rapid test, unlike conventional assays, is able to provide a result within 5 days after receipt of the specimen and could thus play a direct role in the therapeutic decision.

摘要

我们能够使用晚期抗原合成减少试验，直接对临床标本的原代培养物快速测定人巨细胞病毒对更昔洛韦的敏感性。将该试验与传统的敏感性试验进行比较，传统试验是用巨细胞病毒分离和体外传代后获得的无细胞病毒进行的。两种试验产生了相似的结果。与传统试验不同，快速试验能够在收到标本后5天内给出结果，因此可以在治疗决策中发挥直接作用。