Korzaia L I, Shevtsova Z V, Dzhelieva Z N, Krylova R I, Belova E G, Chalian V G
Vopr Virusol. 1992 Jul-Aug;37(4):187-91.
Data on high susceptibility of Papio hamadryas to HAV are presented. For the first time, P. hamadryas were shown to be able to respond to both natural and experimental infection developing the features typical of hepatitis A: increased aminotransferase activity, virus shedding in feces, production of anti-HAV IgG and IgM, histological liver lesions. An infection lingering for 3-4 months was observed, as well as a case of chronic experimental hepatitis A with relapse in 7 months of the disease. Virological evidence of HAV infection was obtained in both lingering and chronic disease. HAV-PH strain was isolated for the first time and is described at length. It was isolated from a baboon with spontaneous infection which did not differ from that in man by antigenic and morphological features. The virus replicated in continuous African green monkey kidney cell line (AGMK) and was pathogenic for P. hamadryas. The HAV-PH isolate can be used for modelling hepatitis A in P. hamadryas.
本文呈现了有关阿拉伯狒狒对甲型肝炎病毒（HAV）高度易感性的数据。首次发现，阿拉伯狒狒能够对自然感染和实验性感染作出反应，出现甲型肝炎的典型特征：转氨酶活性升高、粪便中排出病毒、产生抗-HAV IgG和IgM、肝脏组织学病变。观察到感染持续3至4个月，以及1例在疾病7个月时复发的慢性实验性甲型肝炎病例。在持续性感染和慢性疾病中均获得了HAV感染的病毒学证据。首次分离出HAV-PH毒株并进行了详细描述。它是从一只自然感染的狒狒中分离出来的，其抗原和形态特征与人类感染的病毒并无差异。该病毒能在非洲绿猴肾连续细胞系（AGMK）中复制，且对阿拉伯狒狒具有致病性。HAV-PH分离株可用于在阿拉伯狒狒中模拟甲型肝炎。
