Shevtsova Z V, Krylova R I, Belova E G, Korzaia L I, Andzhaparidze A G
Vopr Virusol. 1987 Nov-Dec;32(6):686-90.
This is the first report of virologically verified spontaneous hepatitis A in M. rhesus monkeys with severe involvement of the liver leading to the death of the animals. In 21 out of 23 dead monkeys morphological lesions in the liver have been characterized as acute hepatitis. In 6 (26%) animals no other pathological processes were found. In 15 animals hepatitis was combined with other diseases (dysentery, parasitic infestations, coronavirus infection). Antigen of hepatitis A virus was detected by an enzyme immunoassay in the intestinal contents of 8 monkeys and in the livers of 3 of them. Immune electron microscopic studies detected in the intestines some virus particles morphologically and antigenically similar to human hepatitis A virus.
这是关于恒河猴发生经病毒学证实的自发性甲型肝炎的首例报告，肝脏严重受累导致动物死亡。23只死亡猴子中有21只肝脏的形态学病变被判定为急性肝炎。6只（26%）动物未发现其他病理过程。15只动物的肝炎与其他疾病（痢疾、寄生虫感染、冠状病毒感染）合并存在。通过酶免疫测定法在8只猴子的肠道内容物及其中3只猴子的肝脏中检测到甲型肝炎病毒抗原。免疫电子显微镜研究在肠道中检测到一些形态和抗原性与人甲型肝炎病毒相似的病毒颗粒。
