[猕猴甲型肝炎的建模]

[The modelling of hepatitis A in macaques].

作者信息

Korzaia L I, Shevtsova Z V, Krylova R I, Belova E G, Dzhelieva Z N, Bystrova T N, Kopnina E O, Aleĭnik M D

出版信息

Vopr Virusol. 1991 Jan-Feb;36(1):13-6.

Abstract

Characteristics of experimental hepatitis A in Macaca fascicularis and M. mulatta produced with HAV, strain MP, isolated from M. mulatta in an outbreak of spontaneous hepatitis are presented. The HAV-MP strain induced the disease in all the animals used in the experiment. The infection was manifest, with all virological, serological, biochemical and morphological features typical of hepatitis A. In M. mulatta, the process was protracted, with virus persistence in feces for at least 4 months. Modeling of hepatitis A in Macaca monkeys using HAV-MP strain may be used for the study of the pathogenesis and trials of immune preparations.

摘要

本文介绍了用从恒河猴自然爆发性肝炎中分离出的甲型肝炎病毒（HAV）MP株，在食蟹猴和恒河猴中引发实验性甲型肝炎的特征。HAV-MP株在实验所用的所有动物中均引发了疾病。感染表现明显，具有甲型肝炎所有典型的病毒学、血清学、生化和形态学特征。在恒河猴中，病程迁延，病毒在粪便中持续存在至少4个月。使用HAV-MP株在猕猴中模拟甲型肝炎可用于发病机制研究和免疫制剂试验。