The Henry Phipps Institute, University of Pennsylvania, Philadelphia.
J Exp Med. 1931 Jul 31;54(3):387-97. doi: 10.1084/jem.54.3.387.
Tuberculin from the human and from the bovine type of tubercle bacilli inhibits the growth of cells from explants of bone marrow, spleen and testes of tuberculous guinea pigs, and is toxic for these cells, but has no effect on explants of the same tissues from non-tuberculous animals. "Tuberculin" from other acid-fast bacteria has no inhibitory or toxic action on explants of tissues from either tuberculous or non-tuberculous guinea pigs. Tuberculins from the avian, bovine and human types of tubercle bacillus as well as "tuberculin" prepared from the Duval and from the Kedrowsky strains of M. leprae inhibit the growth of the cells of explants of the spleen and bone marrow of tuberculous fowls and are toxic for these cells, but have no effect on the explants from tissues of non-tuberculous chickens. "Tuberculins" from other acid-fast bacteria have no effect on the growth of explants of tissues from tuberculous or from non-tuberculous fowls. Tissue culture methods indicate that the sensitivity of tuberculous tissues to tuberculin is inherent in the cell, and that it cannot be passively transferred.
结核菌素（人型和牛型结核杆菌）抑制来自结核豚鼠骨髓、脾脏和睾丸的组织外植体的细胞生长，并且对这些细胞有毒性，但对来自非结核动物的相同组织的外植体没有影响。来自其他抗酸杆菌的“结核菌素”对来自结核或非结核豚鼠的组织外植体没有抑制或毒性作用。禽型、牛型和人型结核分枝杆菌的结核菌素以及从 Duval 和 Kedrowsky 株麻风分枝杆菌制备的“结核菌素”抑制来自结核家禽脾脏和骨髓的组织外植体的细胞生长，并对这些细胞有毒性，但对来自非结核鸡组织的外植体没有影响。来自其他抗酸杆菌的“结核菌素”对来自结核或非结核家禽的组织外植体的生长没有影响。组织培养方法表明，结核组织对结核菌素的敏感性是细胞固有的，不能被动转移。
