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关于萘啶酸在酿酒酵母中的作用研究。

Studies on the action of nalidixic acid in the yeast Saccharomyces cerevisiae.

作者信息

Michaels C A, Blamire J, Goldfinger B, Marmur J

出版信息

Antimicrob Agents Chemother. 1973 May;3(5):562-7. doi: 10.1128/AAC.3.5.562.

DOI:10.1128/AAC.3.5.562
PMID:4597731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444458/
Abstract

The effect of the antibiotic nalidixic acid on macromolecular metabolism in the yeast Saccharomyces cerevisiae has been studied. It was found that, upon the addition of nalidixic acid to a logarithmically growing culture, there is a transient inhibition of total cell ribonucleic acid, deoxyribonucleic acid, and protein synthesis, after which the cells show an almost complete recovery. In addition, there is no preferential inhibition of yeast mitochondrial deoxyribonucleic acid synthesis.

摘要

已对抗生素萘啶酸对酿酒酵母大分子代谢的影响进行了研究。结果发现，向对数生长期培养物中添加萘啶酸后，细胞总核糖核酸、脱氧核糖核酸和蛋白质合成会出现短暂抑制，之后细胞几乎完全恢复。此外，对酵母线粒体脱氧核糖核酸合成没有优先抑制作用。

相似文献

1
Studies on the action of nalidixic acid in the yeast Saccharomyces cerevisiae.关于萘啶酸在酿酒酵母中的作用研究。
Antimicrob Agents Chemother. 1973 May;3(5):562-7. doi: 10.1128/AAC.3.5.562.
2
Inhibition by nalidixic acid of nucleic acid and protein synthesis in Saccharomyces cerevisiae [proceedings].
Biochem Soc Trans. 1977;5(5):1503-5. doi: 10.1042/bst0051503.
3
Effect of putative deoxyribonucleic acid inhibitors on macromolecular synthesis in Saccharomyces cerevisiae.假定的脱氧核糖核酸抑制剂对酿酒酵母中大分子合成的影响。
J Bacteriol. 1970 Jun;102(3):636-41. doi: 10.1128/jb.102.3.636-641.1970.
4
Nalidixic acid causes a transient G1 arrest in the yeast Saccharomyces cerevisiae.萘啶酸会使酿酒酵母出现短暂的G1期阻滞。
Mol Gen Genet. 1979 Oct 2;176(1):37-9. doi: 10.1007/BF00334293.
5
Inhibitors of macromolecular synthesis in yeast.酵母中大分子合成的抑制剂。
Methods Cell Biol. 1975;12:17-38. doi: 10.1016/s0091-679x(08)60949-8.
6
Control mechanism of ribonucleic acid synthesis in eukaryotes. The effect of amino acid and glucose starvation and cycloheximide on yeast deoxyribonucleic acid-dependent ribonucleic acid polymerases.真核生物中核糖核酸合成的控制机制。氨基酸和葡萄糖饥饿以及环己酰亚胺对酵母脱氧核糖核酸依赖性核糖核酸聚合酶的影响。
J Biol Chem. 1974 Jan 25;249(2):568-76.
7
Mechanism of mitochondrial mutation in yeast.
Nat New Biol. 1972 Aug 30;238(87):266-8. doi: 10.1038/newbio238266a0.
8
Toxicity of nalidixic acid on candida albicans, Saccharomyces cerevisiae, and Kluyveromyces lactis.萘啶酸对白色念珠菌、酿酒酵母和乳酸克鲁维酵母的毒性。
Antimicrob Agents Chemother. 1976 Mar;9(3):485-92. doi: 10.1128/AAC.9.3.485.
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Lomofungine as an inhibitor of nucleic acid synthesis in Saccharomyces cerevisiae.洛莫真菌素作为酿酒酵母中核酸合成的抑制剂。
Biochem J. 1974 Sep;142(3):457-63. doi: 10.1042/bj1420457.
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Macromolecule synthesis in yeast spheroplasts.酵母原生质体中的大分子合成。
J Bacteriol. 1967 Nov;94(5):1697-705. doi: 10.1128/jb.94.5.1697-1705.1967.

引用本文的文献

1
Nalidixic acid and macromolecular metabolism in Tetrahymena pyriformis: effects on protein synthesis.萘啶酸与梨形四膜虫的大分子代谢：对蛋白质合成的影响
Antimicrob Agents Chemother. 1975 May;7(5):487-93. doi: 10.1128/AAC.7.5.487.
2
Toxicity of nalidixic acid on candida albicans, Saccharomyces cerevisiae, and Kluyveromyces lactis.萘啶酸对白色念珠菌、酿酒酵母和乳酸克鲁维酵母的毒性。
Antimicrob Agents Chemother. 1976 Mar;9(3):485-92. doi: 10.1128/AAC.9.3.485.
3
Mitochondrial DNA in yeast recombination and subsequent modification following mating between a Grande and a suppressive Petite.酵母中酿酒酵母与抑制性小菌落酵母交配后线粒体DNA的重组及后续修饰
Mol Gen Genet. 1976 Feb 2;143(3):253-9. doi: 10.1007/BF00269401.
4
Nalidixic acid causes a transient G1 arrest in the yeast Saccharomyces cerevisiae.萘啶酸会使酿酒酵母出现短暂的G1期阻滞。
Mol Gen Genet. 1979 Oct 2;176(1):37-9. doi: 10.1007/BF00334293.
5
Population changes induced in Candida albicans by nalidixic acid.萘啶酸对白色念珠菌诱导产生的种群变化。
Mycopathologia. 1979 Sep 17;68(2):105-20. doi: 10.1007/BF00441090.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.萘啶酸对大肠杆菌的作用机制。二、脱氧核糖核酸合成的抑制
J Bacteriol. 1965 Apr;89(4):1068-74. doi: 10.1128/jb.89.4.1068-1074.1965.
3
MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.萘啶酸对大肠杆菌的作用机制
J Bacteriol. 1964 Oct;88(4):1112-8. doi: 10.1128/jb.88.4.1112-1118.1964.
4
SITE OF ACTION OF CYCLOHEXIMIDE IN CELLS OF SACCHAROMYCES PASTORIANUS. I. EFFECT OF THE ANTIBIOTIC ON CELLULAR METABOLISM.环己酰亚胺在巴氏酵母细胞中的作用位点。I. 抗生素对细胞代谢的影响。
Biochim Biophys Acta. 1964 May 18;87:70-82. doi: 10.1016/0926-6550(64)90048-9.
5
The effect of actidione and other antifungal agents on nucleic acid and protein synthesis in Saccharomyces carlsbergensis.放线菌酮及其他抗真菌剂对卡尔斯伯酵母核酸与蛋白质合成的影响。
J Gen Microbiol. 1958 Dec;19(3):497-506. doi: 10.1099/00221287-19-3-497.
6
Nalidixic acid prevents the induction of yeast cytoplasmic respiration-deficient mutants by intercalating drugs.萘啶酸通过插入药物来阻止酵母细胞质呼吸缺陷型突变体的诱导。
FEBS Lett. 1972 May 15;22(3):347-351. doi: 10.1016/0014-5793(72)80267-9.
7
Specific inhibition of chloroplast replication in Euglena gracilis by nalidixic acid.萘啶酸对纤细裸藻叶绿体复制的特异性抑制作用。
J Cell Biol. 1967 Dec;35(3):726-30. doi: 10.1083/jcb.35.3.726.
8
Selective effects of chloramphenicol, cycloheximide and nalidixic acid on the biosynthesis of respiratory enzymes in yeast.氯霉素、环己酰亚胺和萘啶酸对酵母呼吸酶生物合成的选择性作用。
Biochem Biophys Res Commun. 1968 May 10;31(3):474-80. doi: 10.1016/0006-291x(68)90501-9.
9
The action of nalidixic acid on euglena plastids.萘啶酸对眼虫属叶绿体的作用。
J Gen Microbiol. 1970 Apr;61(1):141-4. doi: 10.1099/00221287-61-1-141.
10
Temperature-sensitive yeast mutant defective in ribonucleic acid production.在核糖核酸产生方面存在缺陷的温度敏感型酵母突变体。
J Bacteriol. 1969 Sep;99(3):807-14. doi: 10.1128/jb.99.3.807-814.1969.