Tullus K, Kühn I, Orskov I, Orskov F, Möllby R
Department of Pediatrics, Karolinska Institute, S:t Göran's Children's Hospital, Stockholm, Sweden.
Epidemiol Infect. 1992 Jun;108(3):415-21. doi: 10.1017/s095026880004992x.
The faecal Escherichia coli flora was studied in 89 infants. Each infant was followed with a mean of 12 faecal samples (range 5-21) between 0 and 18 months of age. All isolates were assayed for P fimbriae and biochemically phenotyped and the persistence of each strain (phenotype) in the infant's gut was determined. In a subset of strains the occurrence of type 1 fimbriae and adherence to HeLa cells was studied. Thirty-one per cent of isolates belonging to strains colonizing for longer than 6 months expressed P fimbriae compared to 19% of the isolates from strains colonizing 1-6 months or transient strains colonizing less than 1 month. Type 1 fimbriae and adherence to HeLa cells occurred similarly often in all groups of strains. We conclude that P fimbriae, but not type 1 fimbriae or HeLa cell adherence seemed to contribute to the ability of the E. coli strain to colonize the human intestine.
对89名婴儿的粪便大肠杆菌菌群进行了研究。在0至18个月龄期间，对每名婴儿平均随访了12份粪便样本（范围为5 - 21份）。对所有分离株进行P菌毛检测和生化表型分析，并确定每种菌株（表型）在婴儿肠道中的持久性。在一部分菌株中，研究了1型菌毛的出现情况以及对HeLa细胞的黏附性。在定植超过6个月的菌株中，31%的分离株表达P菌毛，而定植1 - 6个月的菌株或定植少于1个月的短暂菌株中，这一比例为19%。在所有菌株组中，1型菌毛和对HeLa细胞的黏附出现频率相似。我们得出结论，P菌毛似乎有助于大肠杆菌菌株在人类肠道中定植，而1型菌毛或对HeLa细胞的黏附则不然。
