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Ann Rheum Dis. 1976 Aug;35(4):289-96. doi: 10.1136/ard.35.4.289.
2
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Demonstration of link protein in proteoglycan aggregates from human intervertebral disc.人椎间盘蛋白聚糖聚集体中连接蛋白的证实
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PROTEIN-POLYSACCHARIDE COMPLEXES OF NORMAL AND HERNIATED HUMAN INTERVERTEBRAL DISCS.正常和突出的人椎间盘的蛋白质-多糖复合物
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A modified uronic acid carbazole reaction.一种改良的糖醛酸咔唑反应。
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The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.对含有少量这种亚氨基酸的组织和蛋白质样品中羟脯氨酸的测定。
Arch Biochem Biophys. 1961 May;93:440-7. doi: 10.1016/0003-9861(61)90291-0.
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Physical and chemical properties of protamine from the sperm of salmon (Oncorhynchus tschawytscha).来自鲑鱼（大鳞大麻哈鱼）精子的鱼精蛋白的物理和化学性质。
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Age-related variations in proteinpolysaccharides from human nucleus pulposus, annulus fibrosus, and costal cartilage.来自人类髓核、纤维环和肋软骨的蛋白多糖的年龄相关变化。
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6
Proteinpolysaccharide complex from bovine nasal cartilage. The function of glycoprotein in the formation of aggregates.来自牛鼻软骨的蛋白多糖复合物。糖蛋白在聚集体形成中的作用。
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Heterogeneity of protein-polysaccharides of porcine articular cartilage. The sequential extraction of chondroitin sulphate-proteins with iso-osmotic neutral sodium acetate.猪关节软骨蛋白多糖的异质性。用等渗中性醋酸钠对硫酸软骨素蛋白进行顺序提取。
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Proteoglycans of cartilage: an assessment of their structure.软骨蛋白聚糖：其结构评估
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Collagen polymorphism: two molecular species in pig intervertebral disc.
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Aggregation of cartilage proteoglycans. I. The role of hyaluronic acid.软骨蛋白聚糖的聚集。I. 透明质酸的作用。
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人类腰椎间盘蛋白聚糖随年龄的质性变化。

Qualitative changes with age of proteoglycans of human lumbar discs.

作者信息

Adams P, Muir H

出版信息

Ann Rheum Dis. 1976 Aug;35(4):289-96. doi: 10.1136/ard.35.4.289.

DOI:10.1136/ard.35.4.289
PMID:135533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1007385/
Abstract

A detailed study of the biochemistry of each of the lower lumbar intervertebral discs from 3 spines aged 8, 16, and 44 years has shown progressive changes down the spine in a number of biochemical parameters. These were most apparent in the 44-year-old spine. The chemical composition of proteoglycans of the nucleus pulposus and of its constituent proteoglycans differed from those of the corresponding annulus fibrosus of all three spines. The interaction of proteoglycans with collagen, as assessed by extractability, changed markedly with advancing age, while the molecular size of the proteoglycans from both regions decreased and their keratan sulphate content increased. These changes would be expected to affect the mechanical properties of the disc.

摘要

对3具分别为8岁、16岁和44岁脊柱的下腰椎椎间盘进行的详细生物化学研究表明，多个生物化学参数沿脊柱呈现出渐进性变化。这些变化在44岁的脊柱中最为明显。所有三个脊柱的髓核及其组成蛋白聚糖的化学组成均与其相应的纤维环不同。通过可提取性评估的蛋白聚糖与胶原蛋白的相互作用，随着年龄增长而显著变化，而两个区域的蛋白聚糖分子大小均减小，其硫酸角质素含量增加。预计这些变化会影响椎间盘的力学性能。