人类腰椎间盘蛋白聚糖随年龄的质性变化。
Qualitative changes with age of proteoglycans of human lumbar discs.
作者信息
Adams P, Muir H
出版信息
Ann Rheum Dis. 1976 Aug;35(4):289-96. doi: 10.1136/ard.35.4.289.
Abstract
A detailed study of the biochemistry of each of the lower lumbar intervertebral discs from 3 spines aged 8, 16, and 44 years has shown progressive changes down the spine in a number of biochemical parameters. These were most apparent in the 44-year-old spine. The chemical composition of proteoglycans of the nucleus pulposus and of its constituent proteoglycans differed from those of the corresponding annulus fibrosus of all three spines. The interaction of proteoglycans with collagen, as assessed by extractability, changed markedly with advancing age, while the molecular size of the proteoglycans from both regions decreased and their keratan sulphate content increased. These changes would be expected to affect the mechanical properties of the disc.
摘要
对3具分别为8岁、16岁和44岁脊柱的下腰椎椎间盘进行的详细生物化学研究表明，多个生物化学参数沿脊柱呈现出渐进性变化。这些变化在44岁的脊柱中最为明显。所有三个脊柱的髓核及其组成蛋白聚糖的化学组成均与其相应的纤维环不同。通过可提取性评估的蛋白聚糖与胶原蛋白的相互作用，随着年龄增长而显著变化，而两个区域的蛋白聚糖分子大小均减小，其硫酸角质素含量增加。预计这些变化会影响椎间盘的力学性能。
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