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在T细胞受体转基因小鼠中，可溶性肽导致I类主要组织相容性复合体限制性T细胞的胸腺耗竭和外周激活。

Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

作者信息

Mamalaki C, Norton T, Tanaka Y, Townsend A R, Chandler P, Simpson E, Kioussis D

机构信息

Laboratory of Molecular Immunology, National Institute for Medical Research, Mill Hill, London, United Kingdom.

出版信息

Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11342-6. doi: 10.1073/pnas.89.23.11342.

DOI:10.1073/pnas.89.23.11342
PMID:1360667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC50546/
Abstract

Injection of mice transgenic for a class I major histocompatibility complex-restricted T-cell receptor with a soluble peptide antigen from influenza virus nucleoprotein results in clonal depletion of double-positive immature thymocytes in the thymus and activation of mature T cells in the periphery, accompanied by a transient up-regulation of the T-cell receptor and CD3 and CD8 coreceptor molecules.

摘要

向转染了I类主要组织相容性复合体限制型T细胞受体的小鼠注射来自流感病毒核蛋白的可溶性肽抗原，会导致胸腺中双阳性未成熟胸腺细胞的克隆性耗竭以及外周成熟T细胞的激活，并伴有T细胞受体、CD3和CD8共受体分子的短暂上调。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6415/50546/0b8842e779c0/pnas01097-0247-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6415/50546/3f678c1b82ea/pnas01097-0247-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6415/50546/0b8842e779c0/pnas01097-0247-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6415/50546/3f678c1b82ea/pnas01097-0247-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6415/50546/0b8842e779c0/pnas01097-0247-b.jpg

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Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.在T细胞受体转基因小鼠中，可溶性肽导致I类主要组织相容性复合体限制性T细胞的胸腺耗竭和外周激活。
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本文引用的文献

1
Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen.抗体产生的特异性抑制。II. 少量蛋白质抗原诱导成年小鼠麻痹
Immunology. 1962 May;5(3):378-88.
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Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells.细胞毒性T细胞对转染小鼠L细胞中表达的流感核蛋白和血凝素的识别。
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Positive and negative selection of an antigen receptor on T cells in transgenic mice.
影响 CD8αα 上皮内淋巴细胞胸腺选择的因素。
Mucosal Immunol. 2021 Jan;14(1):68-79. doi: 10.1038/s41385-020-0295-5. Epub 2020 Jun 1.
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A role for phagocytosis in inducing cell death during thymocyte negative selection.吞噬作用在诱导胸腺细胞阴性选择过程中细胞死亡中的作用。
Elife. 2019 Dec 23;8:e48097. doi: 10.7554/eLife.48097.
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The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity.树突状细胞主要组织相容性复合体II（MHC II）肽组源自多种加工途径，包括对HLA-DM敏感性范围广泛的肽段。
J Biol Chem. 2016 Mar 11;291(11):5576-5595. doi: 10.1074/jbc.M115.655738. Epub 2016 Jan 6.
6
Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.胸腺调节性T细胞生态位的大小由来自携带抗原的树突状细胞的有限白细胞介素-2和反馈竞争决定。
Nat Immunol. 2015 Jun;16(6):635-41. doi: 10.1038/ni.3171. Epub 2015 May 4.
7
T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity.T细胞特异性抑制多种凋亡途径会阻断阴性选择并导致自身免疫。
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Heme oxygenase-1 regulates dendritic cell function through modulation of p38 MAPK-CREB/ATF1 signaling.血红素加氧酶-1 通过调节 p38 MAPK-CREB/ATF1 信号通路调节树突状细胞功能。
J Biol Chem. 2014 Jun 6;289(23):16442-51. doi: 10.1074/jbc.M113.532069. Epub 2014 Apr 9.
9
The lymph self-antigen repertoire.淋巴细胞自身抗原库。
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Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.共受体对 MHC 的亲和力决定了 TCR 与共刺激肽-MHC 相互作用的肽特异性要求。
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转基因小鼠中T细胞抗原受体的阳性和阴性选择
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4
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.T细胞受体转基因小鼠中的耐受性涉及未成熟CD4+8+胸腺细胞的缺失。
Nature. 1988 Jun 23;333(6175):742-6. doi: 10.1038/333742a0.
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The structure of the human CD2 gene and its expression in transgenic mice.人类CD2基因的结构及其在转基因小鼠中的表达。
EMBO J. 1988 Jun;7(6):1675-82. doi: 10.1002/j.1460-2075.1988.tb02995.x.
6
The T cell receptor from an influenza-A specific murine CTL clone.来自一株甲型流感特异性小鼠细胞毒性T淋巴细胞克隆的T细胞受体。
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7
Association of class I major histocompatibility heavy and light chains induced by viral peptides.病毒肽诱导的I类主要组织相容性重链和轻链的关联
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Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen.双特异性T细胞受体转基因小鼠中的耐受性诱导因抗原而异。
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Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice.人类CD2基因3'侧翼序列在转基因小鼠中赋予高水平、T细胞特异性、位置独立的基因表达。
Cell. 1989 Mar 24;56(6):979-86. doi: 10.1016/0092-8674(89)90631-4.
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Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.在T细胞受体（TCR）转基因小鼠中，自身特异性T细胞的缺失使具有正常TCR水平和低水平CD8分子的细胞得以保留。
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